Center for Medical Genomics

摘要，基因组学核心（GC） 随着人类基因组测序的完成，生物医学科学进入了功能基因组学时代。 新技术提供了极大地增加对生物学的理解的希望，并通过更好的理解， 包括癌症在内的复杂疾病的预防和治疗方法。下一代测序 (NGS)DNA和RNA的相互作用已成为基因组学研究的有力工具。它允许检测和识别 已知的以及新颖的基础水平的变化。它测量基因表达，等位基因特异性表达， 表观基因组变化和整个转录组的选择性剪接。微阵列技术也是强大的， 涉及已知基因元件的实验。SNP基因分型允许确认在 NGS。这些最先进的技术为癌症的功能基因组学提供了全面的方法 research.基于这些基因组工具的研究，无论是在人类还是在模式生物中，都将导致癌症 一个更加个性化治疗的时代。 印第安纳州大学医学院（IUSM）的基因组学核心（GC）提供最先进的基因组学 为印第安纳州西蒙大学癌症中心（IUSCC）的研究者提供服务，包括下一代 测序、单细胞分析、微阵列和高通量基因分型。凭借数十年的经验， 在支持癌症研究方面有着良好的记录，IUSM和IUSCC提供了大量补贴， 与计算生物学和生物信息学中心（CCBB）的联系，GC努力为IUSCC提供 成员以可承受的价格获得高质量的基因组服务，周转时间短。

ABSTRACT, Genomics Core (GC) With the sequencing of the human genome, biomedical sciences have entered the age of functional genomics. New technologies offer the promise of vastly increased understanding of biology, and through that of better approaches to the prevention and treatment of complex disease, including cancer. Next-generation sequencing (NGS) of DNA and RNA has become a powerful tool for genomics study. It allows detection and identification of known as well as novel variations at base level. It measures gene expression, allele-specific expression, epigenomic changes, and alternative splicing of whole transcriptome. Microarray technology is also powerful for experiments involving known gene elements. SNP genotyping allows confirmation of variations discovered in NGS. These state-of-the-art technologies provide comprehensive approaches for functional genomics in cancer research. Studies based on these genomic tools, both in humans and in model organisms, will lead cancer treatment into an era of more individualized treatments. The Genomics Core (GC) at Indiana University School of Medicine (IUSM) provides state-of-the-art genomics services to investigators at Indiana University Simon Cancer Center (IUSCC), including next generation sequencing, single-cell analytics, microarray and high-throughput genotyping. With decades of experience and strong track record in supporting cancer research, significant subsidization from IUSM and IUSCC, and strong ties with the Center for Computational Biology and Bioinformatics (CCBB), the GC strives to provide IUSCC members high-quality genomic services with fast-turnaround times at affordable prices.