Nix mediated mitophagy: A new therapeutic approach to Parkinson's disease

帕金森病(PD)是世界上最常见的神经退行性运动障碍。帕金森病的一个关键问题是，受影响的神经元会失去能量，然后死亡。我们发现，通过回收线粒体(细胞中产生能量的部分)，我们可以保护神经元免于死亡，恢复功能。该项目将确定NIX介导的线粒体再循环是否能够恢复能量并防止神经元丢失。这将是治疗帕金森病的一种新的治疗方法。

Parkinson’s disease (PD) is the most common neurodegenerative movement disorder in the world. A key problem in PD is that affected neurons lose energy and then die. We have discovered that by recycling mitochondria (the parts of the cell that produce energy), we can protect neurons from dying and restore function. This project will determine whether mitochondrial recycling mediated by Nix can restore energy and prevent neuronal loss. This would represent a new therapeutic approach to treat PD.