Administrative/Coordination Core

NexGen阿尔茨海默病模型中心(NG-ADMC)将被行政安置在 加州大学欧文记忆损伤和神经障碍研究所(UCI Mind)。这 UCI的有组织的研究部门管理着NIH资助的ADRC，这是一种专注于阿尔茨海默病的NIH 计划项目补助金、NIA培训补助金和多个其他赠款，需要协调多个 研究人员和多个学科，以实现将改变未来的目标。这个 NexGen阿尔茨海默病模型中心的管理/协调核心(ACC)将提供 协调整个中心，确保财政问责。LaFerla博士和Tenner博士合作 在UCI的多个项目上，补充动物模型、神经炎症和 治疗靶点。具有丰富的管理经验和实验室经验的中心管理员 技术和管理经验，将监督日常交易，组织例行安排的会议， 并有助于财政规划和执行指导委员会将至少每两次召开一次会议 几个月的时间审查数据并讨论对程序、方向或优先顺序的任何修改，以促进 在整个中心取得进展。外部咨询委员会将每六个月召开一次，指导 委员会确认或修改中心的活动，以实现多个单位的里程碑。重要的是，一个 熟悉各种表型特征和实验的项目经理 设计将监督老鼠的日常放置，包括在 中心调查人员。此外，管理人员将维护组织储存库的目录和库存， 在Co-Pis的指导下提供接触试剂/组织的途径，并协调将动物转移到 杰克逊实验室(JAX)。行政协调会将领导中心项目评估活动，包括年度报告 每个核心，并确保各单位之间的沟通，以加快实现里程碑的进展。 ACC将与NIH项目官员沟通中心的活动，并执行收到的建议 来自NIH和EAB的。

The NexGen Alzheimer's Disease Models Center (NG-ADMC) will be administratively housed within the University of California, Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND). This Organized Research Unit at UCI administers the NIH funded ADRC, an Alzheimer's disease focused NIH Program Project Grant, an NIA Training Grant, and multiple other grants, requiring coordination of multiple investigators and multiple disciplines to achieve objectives that will transform the future. The Administrative/Coordination Core (ACC) of the NexGen Alzheimer's Disease Models Center will provide coordination of the entire Center and ensure fiscal accountability. Drs. LaFerla and Tenner have collaborated on multiple projects at UCI with complementing expertise in animal models, neuroinflammation, and therapeutic targetings. A Center Administrator with extensive administrative experience, as well as laboratory technical and management experience, will oversee daily transactions, organize routinely scheduled meetings, and contribute to fiscal planning and execution The Steering Committee will be convened at least every two months to review data and discuss any modification in procedures, direction, or priorities to facilitate the progress across the Center. The External Advisory Board will be convened every six months with the Steering Committee to affirm or modify Center activities toward achieving milestones of the multiple units. Importantly, a Project Manager who is knowledgeable about the various phenotype characterizations and experimental design will oversee the day-to-day placement of mice, including the efficient use of aged animals among the Center investigators. In addition, the Manager will maintain the catalog and inventory of the tissue repository, provide access to reagents/tissues under the guidance of the Co-PIs, and coordinate animal transfers to The Jackson Laboratory (JAX). The ACC will lead Center program evaluation activities, including annual reports of each core, and ensure communication among the units to accelerate progress toward achieving milestones. The ACC will communicate Center activities with the NIH Program Official and implement suggestions received from the NIH and the EAB.