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Modulators of RPS14 with broad antiviral activity

Modulators of RPS14 with broad antiviral activity
具有广泛抗病毒活性的 RPS14 调节剂
批准号：
10255320
负责人：
Noel Southall
金额：
$11.24万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10255320
关键词：
AdenovirusesAntiviral AgentsBindingBiological AssayBiologyCollaborationsDiseaseEmetineExhibitsExtramural ActivitiesGoalsInformaticsModelingPharmaceutical ChemistryPhenotypeProcessReagentResearchResearch PersonnelStructureSynthesis ChemistryTestingTranslationsUnited States National Institutes of HealthValidationWorkassay developmentbasebiophysical techniquesdesigndrug developmentdrug discoverylead optimizationnew technologynovelscreeningsmall moleculesmall molecule therapeuticstherapeutic developmenttoolvirtual screening

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中文摘要
翻译
这个合作团队的目标是通过发现RPS14的新型调节剂来建立以前的研究。 例如，依美汀与RPS14结合表现出广泛的抗病毒活性。 在此期间，合作团队使用虚拟筛选方法确定了候选RPS 14粘合剂。 使用生物物理方法测试分子的RPS 14结合，并在腺病毒复制测定中评估活性。 该团队将进行结构研究和设计试剂，以确认作用机制。
英文摘要
This collaborative team aims to build on previous research by uncovering novel modulators of RPS14. Emetine, for example, binds to RPS14 exhibits broad antiviral activity. During this period, the collaborative team has identified candidate RPS14 binders using a virtual screening approach. Molecules were tested for RPS14 binding using biophysical approaches and activity was assessed in adenovirus replication assays. The team will pursue structural studies and design reagents to confirm an on-target mechanism of action.
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