Non-coding RNA regulation of virulence in enterohaemorrhagic E. coli

滋贺毒素可引起潜在的致命性溶血性尿毒综合征（HUS），并通过噬菌体（细菌病毒）在细菌病原体之间转移。我们最近发现编码滋贺毒素的噬菌体编码异常大量的非编码RNA（基因表达的RNA调节子）。该项目旨在了解这些RNA调节剂如何使滋贺毒素噬菌体受益，并利用这些知识开发预防毒素表达的干预措施。

Shiga toxins cause potentially fatal haemolytic uremic syndrome (HUS) and are transferred between bacterial pathogens by bacteriophage (bacterial viruses). We have recently found that the Shiga toxin encoding bacteriophage encodes an unusually large number of non-coding RNAs (RNA regulators of gene expression). This Project aims to understand how these RNA regulators benefit the Shiga toxin bacteriophage and use this knowledge to develop interventions that will prevent expression of the toxin.