Comparison of Hemorrhagic & Ischemic Stroke Among Blacks and Whites

项目概要： 我们寻求继续我们的基于人群的中风发病率和病死率的研究， 因素、卒中治疗和卒中后结局，在1，368，604名 其中223，417人（16.3%）是黑人（美国人口普查2010）。我们预计将确定约4500名医生确认 和充分表征的卒中事件（预计2900例缺血性卒中、525例出血性卒中和1075例 在大辛辛那提/北方肯塔基州的五个县的居民中， 2019年7月1日至2020年12月31日期间，所有20家地区医院/急诊室的GCNK区域，以及2，000份调查 参与者 近25年来，我们一直在研究中风发病率和病死率的趋势， 种族差异，非裔美国人的中风发病率是白人的两倍多。在每一个先前 研究期间，我们还通过人群检查了危险因素（和卒中知识）的患病率 调查，以便将我们的时间趋势调查结果纳入背景。 除了继续这些重要的活动外，我们还检查了人群中的卒中复发情况- 在我们之前的研究中，我们发现黑人更容易发生复发性事件， 白人我们现在试图评估复发率的时间趋势，特别是种族差异， 这些时间趋势。以前，我们曾试行过一些方法，以获得基于人口的结果， 中风患者，我们现在已经准备好在我们整个人群中获得缺血性中风后的结果， 这些数据是这个领域急需的。最后，我们使用我们的数据来告知中风的资格 通过与NIH StrokeNet的密切合作进行临床试验，并与科学家分享我们的数据。 社区为此。通过获得更详细的结果数据，我们现在能够更好地了解 也提出了恢复和预防试验。

PROJECT SUMMARY: We seek to continue our population-based study of stroke incidence and case fatality, prevalence of risk factors, stroke treatment, and post-stroke outcomes within a biracial metropolitan population of 1,368,604 of whom 223,417 (16.3%) are of black race (US Census 2010). We expect to identify ~4500 physician confirmed and well characterized stroke events (projected 2900 ischemic strokes, 525 hemorrhagic strokes, and 1075 transient ischemic attack [TIA]) among residents of the five-county Greater Cincinnati/Northern Kentucky (GCNK) region at all 20 regional hospitals/EDs for the period 7/1/2019 to 12/31/2020, as well as 2,000 survey participants. For almost 25 years, we have studied trends in stroke incidence and case fatality and have demonstrated a racial disparity where stroke incidence in African-Americans is more than double that of whites. In each prior study period, we have also examined the prevalence of risk factors (and knowledge of stroke) via a population survey in order to put our temporal trend findings into context. In addition to continuing these important activities, we also examined stroke recurrence in a population- based fashion in our prior study period, finding that blacks were more likely to have recurrent events than whites. We now seek to evaluate temporal trends in recurrence rates, and specifically racial disparities in those temporal trends. Previously we had piloted methods of obtaining a population-based outcome among stroke patients, and we are now ready to obtain outcomes after ischemic stroke across our entire population, data that are desperately needed in the field. Finally, we have used our data to inform eligibility for stroke clinical trials via a close collaboration with NIH StrokeNet and have shared our data with the scientific community for this purpose. By obtaining more detailed outcomes data, we will now be able to better inform proposed recovery and prevention trials as well.