Inhibitory synaptic plasticity during learning

摘要 大脑通过什么神经回路来区分偶然和有意义 环境输入，使长期持久的变化，在感觉和行为？实验 有证据表明这种区别可以在皮层处理的最早阶段进行， 在初级感觉皮层。在这里，我们将使用高通量，自动化的行为训练， 自由移动的老鼠，以确定大脑皮层的详细神经回路是如何 在获取基于触觉奖励的关联期间明显改变。我们的初步数据 表明在小清蛋白（PV）介导的突触抑制中的持久修饰是 选择性地由感觉联想训练驱动，而不是被动的感觉暴露， 立足点，以调查细胞回路，区分不同类型的 依赖经验的可塑性使用体内Ca成像，靶向电生理 记录和解剖分析，我们将确定特定的机制， 神经亚型促进皮质柱的学习相关重组。

Abstract What are the neural circuits by which the brain differentiates between incidental and meaningful environmental inputs to enable long-lasting changes in sensation and behavior? Experimental evidence indicates that this distinction may be made at the earliest stages of cortical processing, in primary sensory cortex. Here we will use high-throughput, automated behavioral training in freely-moving mice to determine how the detailed neural circuitry of the cerebral cortex is distinctly changed during acquisition of a tactile reward-based association. Our preliminary data indicate that long-lasting modifications in parvalbumin (PV)-mediated synaptic inhibition is selectively driven by sensory association training but not passive sensory exposure, providing a foothold to investigate the cellular circuitry that distinguishes between different types of experience-dependent plasticity. Using in vivo Ca imaging, targeted electrophysiological recordings and anatomical analyses, we will determine the mechanisms by which specific neural subtypes facilitate learning-related reorganization of the cortical column.