2022 Synaptic Transmission GRC/GRS

项目摘要 突触是健康大脑中通信和信号处理的关键元素。 此外，突触在几种神经和精神疾病中受到严重干扰。这 该提案要求支持召开一次关于突触传递的国际科学会议， 戈登研究会议（GRC）系列将在意大利巴尔加文艺复兴时期的托斯卡纳伊尔乔科举行。 在此之前，将举行一个针对研究生的戈登研究研讨会（GRS）， 6月20日至21日在同一地点举行博士后研究员会议。我们将召集科学家， 对突触功能感兴趣，但在不同水平（分子、细胞和系统）检查突触 层次），从不同的角度（自下而上，自上而下）看待它们，并使用不同的方法 （分子生物学，超分辨率成像，3D和冷冻电子显微镜，光遗传学，亚细胞 电生理学、建模和许多其他）。系列会议的长期目标是：（1） 增加对突触传递的基本分子和细胞机制的理解，（2） 阐明突触传递如何塑造神经元网络活动，以及（3）将基础科学与 突触来理解疾病的过程。我们建议在这一非常成功的战略基础上， 传统的会议，以及执行创新战略，以确定和支持下， 代表少数群体，并利用导师-学员计划吸引学员和知名科学家。 30位承诺的演讲者将代表突触传递研究的关键领域， 在意大利的巴尔加，与会者在一个类似务虚会的环境中参加了一个为期五天的紧张会议。节目将开始 该领域的领导者冯国平将在全体会议上谈论使用转基因技术， 研究与自闭症有关的突触功能障碍。八次会议将讨论突触 从突触前和突触后的角度，包括：结构，可塑性，信号，人工 突触网络，病理学，与突触周星形胶质细胞的关系，以及突触在 复杂的系统在所有四天的简短会谈和晚上海报会议将允许广泛的参与， 实习生和初级教员。最后一次全体会议将由罗布·马伦卡（Rob Malenka）主持， 研究神经突触可塑性的科学家。这与健康和疾病的相关性 应用是实质性的。虽然许多演讲将集中在基础科学，数据已经远远- 对以突触病变形式出现的破坏性大脑疾病的影响， 神经变性疾病，如帕金森病和阿尔茨海默病，情绪障碍，精神分裂症， 自闭症谱系障碍、智力迟钝和药物成瘾。2020 Synaptic Transmission GRC 将在未来十年对基础和疾病相关的神经科学产生重大影响。

Project Summary Synapses are key elements of communication and signal processing in the healthy brain. Furthermore, synapses are severely perturbed in several neurological and psychiatric diseases. This proposal requests support for an international scientific meeting on Synaptic Transmission as part of the Gordon Research Conference (GRC) series to be held at the Renaissance Tuscany Il Ciocco in Barga, Italy. This GRC will be preceded by a Gordon Research Seminar (GRS) targeted towards graduate students and post-doctoral fellows on June 20-21 at the same location. We will bring together scientists who all are highly interested in synaptic function but examine synapses at different levels (molecular, cellular, and systems level), look at them from different perspectives (bottom-up, top-down), and use different approaches (molecular biology, super-resolution imaging, 3D and cryo-electron microscopy, optogenetics, subcellular electrophysiology, modeling, and many others). The long-term objectives of the conference series are (1) to increase understanding of the fundamental molecular and cellular mechanisms of synaptic transmission, (2) to elucidate how synaptic transmission shapes neuronal network activity, and (3) to link basic science on synapses to understanding disease processes. We propose to build on the highly successful strategy of this traditional conference as well as implement innovative strategies for identifying and supporting under- represented minorities, and engaging trainees and established scientists using a mentor-mentee program. Thirty committed speakers will represent critical areas of synaptic transmission research for ~150 participants for an intense five-day conference in a retreat-like setting in Barga, Italy. The program will begin with a plenary session from a leader in the field, Guo-Ping Feng, who will talk about using transgenic marmosets to study synaptic dysfunction related to autism. Eight sessions will then address synaptic transmission from both pre- and postsynaptic perspectives including: structure, plasticity, signaling, artificial synaptic networks, pathology, relationships to perisynaptic astroglia, and the function of synapses in complex systems. Short talks and evening poster sessions on all four days will permit broad participation by trainees and junior faculty members. The final plenary talk will be given by Rob Malenka, a leader in studying synaptic plasticity who has focused on drug addiction. The health and disease relevance of this application is substantial. Although many presentations will focus on basic science, the data have far- reaching implications for devastating brain disorders that are emerging as synaptopathies including neurodegenerative diseases, such as Parkinson's and Alzheimer's disease, mood disorders, schizophrenia, autism spectrum disorders, mental retardation, and drug addiction. The 2020 Synaptic Transmission GRC will have a major influence shaping both basic and disease-related neuroscience across the next decade.