Multimodal preclinical imaging studies of decisional determinants of drug vs non-drug choice

最有效的成瘾治疗之一是应急管理，其中提供替代奖励以换取戒断。我们通过使用触摸屏在实验室动物中建立经济选择来模拟这种方法，触摸屏显示数量表示刺激并检测选择反应。动物所做选择的经济性质通过饱食导致的牛奶奖励贬值或通过盐水替代的药物（瑞芬太尼）奖励来验证。为了操纵特定的电路，我们正在与其他实验室合作开发经颅磁刺激方法，以及灵长类动物的化学遗传工具箱，可以在临床上建立其潜在的应用。

One of the most effective addiction treatments is contingency management, in which alternate rewards are offered in exchange for abstention. We model this approach by establishing economic choice in lab animals using touch screens that display quantity signifying stimuli and detect choice responses. The economic nature of the choices animals make was verified by devaluation of milk reward through satiation, or drug (remifentanil) reward through saline substitution. To manipulate specific circuits, we are collaborating with other labs to develop transcranial magnetic stimulation approaches, as well as a chemogenetic toolbox for primates that could establish their potential application in the clinic.