Non-mutational phenotypic evolution in metastatic melanoma: the role of the epidermal growth factor receptor and epithelial-mesenchymal transition-like processes in treatment resistance.
Non-mutational phenotypic evolution in metastatic melanoma: the role of the epidermal growth factor receptor and epithelial-mesenchymal transition-like processes in treatment resistance.
转移性黑色素瘤的非突变表型进化：表皮生长因子受体和上皮间质转化样过程在治疗抵抗中的作用。
批准号：
nhmrc : 1055456
负责人：
Dr Miles Andrews
金额：
$9.4万
依托单位：
依托单位国家：
澳大利亚
项目类别：
Postgraduate Scholarships
财政年份：
2013
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2013-01-01 至 2016-12-31
中文摘要
翻译
表型改变已被确定在多种设置有关黑色素瘤的进展和转移。我们已经确定了表型可塑性、上皮细胞向间质转化和治疗耐药性的出现之间存在一定程度的重叠。本项目将进一步研究这些变化的机制，重点研究表皮生长因子的作用。
英文摘要
Phenotypic change has been identified in multiple settings relating to melanoma progression and metastasis. We have identified a degree of overlap between features of phenotypic plasticity, epithelial-to-mesenchymal transition, and the emergence of treatment resistance. This project will further examine mechanisms underlying these changes, focusing on the role of the epidermal growth factor.
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会议论文
Deriving actionable strategies to enhance cancer immunotherapy response
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批准号：nhmrc : 1148680
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项目类别：Early Career Fellowships
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资助金额：$29.82万
-
财政年份：2018
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负责人：Dr Miles Andrews
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依托单位：
Deriving actionable strategies to enhance cancer immunotherapy response
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批准号：nhmrc : GNT1148680
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项目类别：Early Career Fellowships
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资助金额：$43.88万
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财政年份：2018
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负责人：Dr Miles Andrews
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依托单位：
Characterisation of the role of mesenchymal phenotypes and EGFR in treatment-resistant melanoma.
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批准号：nhmrc : GNT1055456
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项目类别：Postgraduate Scholarships
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资助金额：$11.32万
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财政年份：2013
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负责人：Dr Miles Andrews
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依托单位：
海外基金
