Integrative Training in Oncogenic Signaling

项目摘要/摘要 首次续签申请寻求美国国家癌症研究所(NCI)的持续支持，以获得成功的综合 培训致癌信号‘(ITOS)计划是为了培训博士后研究员，由一组选定的 隶属于南卡罗来纳医科大学霍林斯癌症中心的癌症科学家 (MUSC)。该计划发生在一个活跃和不断增长的医疗中心，拥有最先进的设施，一个充满活力的 NCI指定的癌症中心，以及一个活跃的博士后事务办公室。由计划主管团队领导 凭借异常强大的癌症研究和领导背景，ITOS计划选择和 支持将受训人员安置在由该方案领导的经验丰富、资金充足、富有成效的实验室 居住在交互式、多部门研究环境中、拥有广泛资源的教职员工。每个人 学员有一名主要导师和一名/两名二级导师，他们具有互补的专业知识，以确保 和有价值的观点，提高与癌症相关的整体研究培训经验。目标 信息技术组织方案的执行情况保持不变，力求提供积极的指导、监督和研究培训 在前沿方法方面；发展有用的学术和基本的职业发展技能；促进 与教员和其他实习生进行协作、跨学科的互动；并提供对当前 癌症研究发现以及如何将这些发现转化为预防、诊断和治疗癌症的新方法， 治疗癌症。ITOS方案有七个基本方案组成部分：1)33个成员方案 具有共同癌症研究兴趣并为学员提供基本指导的教职员工；2)1至 在指定的项目学院实验室工作两年；3)ITOS项目研究俱乐部提供 一个有吸引力的社区论坛，供受训者和计划教职员工讨论正在进行的工作以及 最新发现；4)尖端生物技术方面的共享研究资源讲习班和量身定制的培训； 5)与受训人员进行跨学科接触，参加由CC赞助的专题研究务虚会、座谈会、工作 进度会议和研讨会；6)职业发展讲习班和课程，使受训人员具备 独立成功；以及，7)至少在两次专业会议上在全国范围内建立网络的机会 每年。在它的第四年，ITOS方案已经毕业了9名研究员；1名博士，1名博士/博士，7名博士。受训人员来自 背景多样，58%是女性，30.8%是代表不足的种族/族裔少数群体，他们都有 成功地过渡到学术界或工业界的职位。基于以下各项的能力、容量和发展轨迹 MUSC癌症相关培训，以及在最初的供资期间取得的成功成就， ITOS计划要求每年支持7名博士后实习生，这意味着增加了 两个实习生职位。总而言之，我们的ITOS计划只提供独特的体验和机会 提供给选定的ITOS研究员，该方案由一名杰出的方案学院干部领导， 预计将对当地和全国新兴的初级调查人员保持极大的吸引力。

PROJECT SUMMARY/ABSTRACT This first renewal application seeks continued National Cancer Institute (NCI) support for a successful ‘Integrative Training in Oncogenic Signaling’ (ITOS) Program developed to train postdoctoral fellows by a select group of cancer scientists affiliated with the Hollings Cancer Center (HCC) at the Medical University of South Carolina (MUSC). The programtakes place in an active and growing medical center with state -of-the-art facilities,a vibrant NCI-designated cancer center, and an active Office of Postdoctoral Affairs. Led by a Program Directorship team with an exceptionally strong cancer research and leadership background, the ITOS Program selects and supports the placement of trainees in experienced, well-funded, productive laboratories led by the Program Faculty who reside in an interactive, multi-departmental research environment with extensive resources. Each trainee has a primary mentor and one/two secondary mentors with complementary expertise to ensure distinct and valuable perspectives that enhances the overall cancer-relatedresearch training experience. The objectives of the ITOS Programremain unchanged, seeking to provideproactive mentoring, oversight and research training in cutting-edge methodology; to develop useful academic and essential career development skills; to foster collaborative, interdisciplinary interactions with faculty and other trainees; and, to provide exposure to current cancer research discoveries and how these are being translated into novel approaches to prevent, diagnosis, and treat cancer. The ITOS Program has seven essential programmatic components: 1) 33 member Program Faculty who share common cancer research interests and provide essential mentoring for trainees; 2) one to two year experiences in designated Program Faculty laboratories; 3) an ITOS Program Research Club providing an engaging community forum for the trainees and Program Faculty to discuss work in progress as well as the latest discoveries; 4) shared research resource workshops and tailored training in cutting-edge biotechnologies; 5) interdisciplinary engagement with trainees in HCC-sponsored thematic research retreats, symposia, work in progress meetings, and seminars; 6) career development workshops and courses that equip trainees for independent success; and, 7) opportunities to network nationally at a minimum of two professional conferences each year. In its fourth year, the ITOS Program has graduated 9 fellows; 1MD, 1MD/PhD, 7 PhDs. Trainees from diverse backgrounds, 58% female and 30.8% underrepresented racial/ethnic minorities, whom have all successfully transitioned to positions in academia or industry. Based on the capabilities, capacity, trajectory of MUSC for cancer-related training, and the successful accomplishments achieved during its initial funding period, the ITOS Program is requesting the support for seven postdoctoral trainees each year, representing an increase of two trainee positions. In summary, our ITOS Program offers distinct experiences and opportunities only afforded to the selected ITOS Fellows, and the program, led by an outstanding cadre of Program Faculty, is anticipated to remain highly attractive to emerging junior investigators locally and nationally.