West Virginia Pediatric Clinical Trials Network-2

摘要 西弗吉尼亚州(西弗吉尼亚州)具有长期的身体、心理和财政特征，包括阿片类药物 危机、有限的资源和有限的经济对其居民的健康产生了重大影响。 西弗吉尼亚州儿科临床试验网络(WVPCTN)，作为ECHO IDEA州PCTN的临床站点 (ISPCTN)通过履行其使命，催生了新的解决方案，以解决其中一些负担。 具体地说，WVPCTN的使命有两个--将临床试验带给我们服务不足的人群， 建设临床研究的专业能力。我们的西弗吉尼亚大学网站已经做好了很好的定位，将成为一个成功的 临床站点由于结构和人力资源的组合，在ISPCTN时已经到位 该项目于2016年启动，介绍了索尔博士、派尔斯博士和科特雷尔博士这三位执行主任的背景和专业知识。这个 ISPCTN提供的资金和资源的增加导致了WVU能力的加速，以积极 通过允许我们创建专门的儿科研究单位(PRU)并引入 一组初级、经验较少的临床试验研究人员，参与ISPCTN和非ISPCTN试验。这个 这种方法的有效性已经通过ISPCTN中教职员工参与的增加而得到证明 西弗吉尼亚大学的活动、强劲的招募记录以及非ISPCTN儿科试验的数量增加。 WVPCTN现在正在积极发展一支经验丰富的调查员队伍和一批受训调查员，他们都是 由西弗吉尼亚临床翻译科学研究所(WVCTSI)的资源和专业知识加强。 这些功能和资源，加上全州牢固和持久的合作伙伴关系，以及 我们公民的多种与环境有关的条件，继续独特地定位我们作为 ISPCTN临床网站，并努力为该网络提出新的试验建议。这项关于WVPCTN-2的提案将进一步 增加了对全州以儿科为重点的倡议的长期承诺。一旦获得资金，它将继续 使我们能够充分利用额外资金来支持儿科研究基础设施并提供 到尖端试验，这两者都将对西弗吉尼亚州儿童的健康产生积极影响。

Abstract West Virginia (WV) bears long-standing physical, psychosocial and fiscal characteristics, including the opioid crisis, limited resources and a restricted economy, that have significantly impacted the health of its residents. The West Virginia Pediatric Clinical Trials Network (WVPCTN), as a Clinical Site of the ECHO IDeA States PCTN (ISPCTN), has catalyzed emerging solutions to address some of these burdens by fulfilling its mission. Specifically, the mission of the WVPCTN has been two-fold - bringing clinical trials to our underserved population, and building professional capacity for clinical research. Our WVU site has been well positioned to be a successful Clinical Site due to a combination of structural and human resources that were already in place when the ISPCTN was initiated in 2016, and the background and expertise of the three PIs – Drs. Saul, Pyles and Cottrell. The addition of the funds and resources provided by ISPCTN led to an acceleration of WVUs capacity to actively participate in clinical trials by allowing us to create a dedicated Pediatric Research Unit (PRU) and introduce a group of junior, less experienced clinical trial investigators, into both ISPCTN and non-ISPCTN trials. The effectiveness of this approach has been demonstrated through an increase in faculty participation in ISPCTN activities, a strong recruitment record, and an increase in the number of non-ISPCTN Pediatric trials at WVU. The WVPCTN is now actively growing an experienced investigator pool and a group of mentee investigators, all enhanced by the resources and expertise of the West Virginia Clinical Translational Science Institute (WVCTSI). These features and resources, together with strong and sustained partnerships throughout the state, and the multiple environmentally related conditions of our citizens, continue to uniquely position us to be successful as an ISPCTN Clinical Site and work to propose new trials for the network. This proposal for WVPCTN-2 will further add to a long-standing commitment to Pediatric-focused initiatives across the state. When funded, it will continue to position us to fully leverage additional funds that support Pediatric research infrastructure and provide access to cutting edge trials, both of which will positively impact the health of the children of WV.