Cellular and Synaptic Hypothalamic Reorganization After Exercise Training

体力活动提供多种代谢益处，包括改善胰岛素敏感性和身体健康。 混合物.在大脑内部，关于运动对急性改变突触/细胞的影响知之甚少。 以及这些影响如何改变新陈代谢。在目前的提案中，我们发现， CNS衍生的GLP-1神经元响应于运动而被激活。此外，GLP-1和GLP-1模拟物 模拟运动对弓状黑皮质素神经元的影响。总的来说，这些数据支持这一假设 NTS GLP-1至弓形POMC回路响应于运动而被激活。我们将识别出 运动激活GLP-1和黑皮质素神经元的机制。我们还将确定一个角色 这些急性/慢性细胞机制来调节新陈代谢。

Physical activity provides multiple metabolic benefits, including improved insulin sensitivity and body composition. Within the brain, less is known about the effects of exercise to acutely alter synaptic/cellular properties and how these effects contribute to altered metabolism. In the current proposal, we have found that CNS derived GLP-1 neurons are activated in response to exercise. Moreover, GLP-1 and GLP-1 mimetics mimic the effects of exercise on arcuate melanocortin neurons. Collectively, these data support the hypothesis that an NTS GLP-1 to arcuate POMC circuit is activated in response to exercise. We will identify cellular mechanisms through which exercise activates GLP-1 and melanocortin neurons. We will also determine a role for these acute/chronic cellular mechanisms to regulate metabolism.