Admin-Core

管理核心摘要 由NIDDK资助的儿科肾脏病学卓越中心重点关注 提高效率，促进成功调查人员之间的协作 在已建立综合肾脏研究基地的机构。我们提出了一个 费城儿童医院（CHOP）儿科中心的行政结构 卓越的肾脏病学，将形成同事之间的跨学科伙伴关系， 具有设计和分析观察性研究和临床试验的专业知识， 在学习卫生系统内成功启动儿科临床试验， 在研究方法、临床表型分析和研究培训方面的良好记录。的 除了行政核心外，CHOP-PCEN将有三个生物医学研究核心; a 设计和分析核心，临床表型核心，重点关注营养/CVD风险因素， 骨骼健康和学习健康系统核心，以及试点和可行性计划， 浓缩堆芯和利用这些堆芯的两个研究项目提案。的总体目标 行政核心是为整个PCEN提供方向，指导和监督， 确保其有效和高效运作。行政核心将与 参与我们的研究基地，其中包括39名研究人员，共150个资助项目， 每年直接成本超过3500万美元。其中超过1200万美元的资金直接与以下方面有关： 由核心服务的潜在用户领导的儿科肾病学。

ADMINISTRATION CORE ABSTRACT The Pediatric Centers of Excellence in Nephrology funded by the NIDDK provide a focus to increase efficiency and promote collaborative efforts among groups of successful investigators at institutions with established comprehensive kidney research bases. We propose an administrative structure for the Children’s Hospital of Philadelphia (CHOP) Pediatric Center of Excellence in Nephrology that will form an interdisciplinary partnership between colleagues with expertise in design and analysis of observational studies and clinical trials, with individuals successful in initiating pediatric clinical trials within learning health systems, and colleagues with proven track records in research methods, clinical phenotyping and research training. The CHOP-PCEN will have three biomedical research cores in addition to the Administrative core; a Design and Analysis core, a Clinical phenotyping core focused on Nutrition/CVD risk factors and Bone health, and a Learning Health System Core, as well as a pilot and feasibility program, an enrichment core and two research project proposals utilizing the cores. The overall goal of the administrative core is to provide direction, guidance and oversight for the entire PCEN and assure its effective and efficient functioning. The Administrative core will interact with and engage our research base which includes 39 investigators, with 150 funded projects totaling over $35 million in annual direct costs. Over $12 million of this funding is directly relevant to pediatric nephrology led by likely users of the core services.