Project-Pilots

拟议中的罗伊巴尔中心试点核心的中心目标是启动和完成NIH第0-III阶段 研究表明，中心调查人员竞争独立资金以实现IV-V阶段的有效性和 长期改善痴呆症患者姑息治疗干预措施的实施试验 服务和支持(LTSS)设施。为了实现其选择和支持试点项目的主要目标， 将行为经济学和数据科学的想法转化为改善居住在 LTSS设施，指导委员会将每年向所有附属机构发出申请请求 调查人员和他们的实习生。飞行员核心派杰森·卡拉维什、医学博士和其他委员会成员将对 每一项申请都有七个标准，并使用NIH 9分量表为每个申请打一个总分。这个 然后，委员会将推荐得分最高的飞行员进行最终资金决定，以(1)罗伊巴尔中心的 咨询委员会；(2)Genesis保健领导(用于在Genesis范围内提出研究的项目 设施)；以及(3)国家安全局官员和罗伊巴尔协调中心。 Pilot Core还有另外三个具体目标。首先，我们的目标是指导初级教师和博士后研究员 开发和测试行为改变干预措施。几位指导委员会成员和众多 附属调查人员是领先的行为研究导师，并在很大程度上致力于 他们的职业生涯变成了导师。我们预计初级调查人员将在至少一半的试点中占据突出地位 通过该中心支持的项目，并将利用该中心的年度研讨会启动新的指导 初级和高级调查人员之间的关系。第二，我们的目标是促进 中心的附属调查人员，特别是通过将那些在0-III阶段行为干预方面具有专业知识的人联系起来 研究人员拥有行为经济学、数据科学、 定性方法、统计学和实施学。这些行为科学家之间的合作 方法学家将使我们能够开发可扩展的干预措施，显著改善结果。 第三，Pilot Core将为所有Roybal提供集中数据和安全监测计划和监督 中心飞行员。飞行员核心皮卡拉维什和总体皮哈尔彭都是研究伦理方面的专家。在……里面 他们将与该中心经验丰富的高级工作人员一起开发数据和安全监测 将所有试点项目的计划作为中心的共享资源。该试点核心提出了阶段I和阶段0 第一年申请资助的项目，并详细介绍了这些项目。这两个试点项目被选中 在为准备本中心建议书而首次征集申请之后。尽管这个最初的呼叫操作 在缩短的时间内，提交了许多特殊申请。因此，我们还提供了简短的 说明将在未来几年考虑供资的其他四项示范性提案。

The central goal of the Pilot Core of this proposed Roybal Center is to launch and complete NIH Stage 0-III studies that position Center investigators to compete for independent funding for Stage IV-V effectiveness and implementation trials of interventions to improve palliative care for persons with dementia (PWD) in long-term services and support (LTSS) facilities. To achieve its primary goal of selecting and supporting pilot projects that translate ideas from behavioral economics and data science into improvements in care for PWD residing in LTSS facilities, the Steering Committee will issue an annual request for applications to all Affiliated Investigators and their trainees. Pilot Core PI Jason Karlawish, MD and other Committee members will rate each application on seven criteria and assign each an overall score using the 9-point NIH scale. The Committee will then propose the highest-scored pilots for final funding decisions to (1) the Roybal Center's Advisory Committee; (2) the Genesis HealthCare leadership (for projects proposing studies within Genesis facilities); and (3) NIA officials and the Roybal Coordinating Center. The Pilot Core has three other specific aims. First, we aim to mentor junior faculty and post-doctoral fellows in developing and testing behavior change interventions. Several Steering Committee members and numerous Affiliated Investigators are leading behavioral research mentors, and have committed substantial portions of their careers to mentorship. We expect junior investigators to feature prominently in at least half of the pilot projects supported through this Center, and will use the Center's annual Symposium to launch new mentoring relationships among junior and senior investigators. Second, we aim to foster new collaborations among the Center's Affiliated Investigators, particularly by linking those with expertise in Stage 0-III behavioral intervention research with investigators who possess methodological expertise in behavioral economics, data science, qualitative methods, statistics, and implementation science. These collaborations between behavioral scientists and methodologists will enable us to develop scalable interventions that measurably improve outcomes. Third, the Pilot Core will provide centralized data and safety monitoring plans and oversight for all Roybal Center pilots. Pilot Core PI Karlawish and Overall PI Halpern are both experts in research ethics. In conjunction with the Center's highly experienced senior staff, they will develop data and safety monitoring plans for all pilot projects as a shared resource of the Center. This pilot core proposes a Stage I and a Stage 0 project for funding in year 1, and describes these projects in detail. These two pilot projects were selected following an initial call for applications in preparation of this Center proposal. Although this initial call operated on an abridged timeline, many exceptional applications were submitted. We therefore also provide brief descriptions of four other exemplary proposals that will be considered for funding in future years.