TOPIC 383: MULTI-CORE BIOPSY DEVICE WITH VOLUMETRIC FIELD OF TISSUE ACQUISITION (MOONSHOT)

问题：肿瘤复发或对治疗的抵抗往往是由于肿瘤的异质性而引起的。有必要 开发智能活检设备：1）从多个肿瘤核心收集活检; 2）识别活检位置; 3） 保持提取样本上肿瘤的物理特性; 4）在当前图像引导下使用 实践我们建议进一步开发我们已经开发的多芯活检装置（MCBD）的原型 以使得能够在活检针周围的体积中收集多芯组织样本。我们希望提供原型 能够在电磁定位下快速采集和保存多个组织核心的设备 导航如果成功，该项目将具有巨大的商业潜力，因为拟议的设备将促进 在任何组织类型和任何针尺寸中采集多个组织芯， 通过更好地保存和处理组织样品来进行生物分子分析。这项研究对 公共卫生，因为它可以通过缩短图像引导活检程序来降低医疗保健成本，并且它可以改善患者 通过更好地匹配肿瘤类型和基于肿瘤综合评估的特定治疗来管理 以及更好的组织保存

The problem: Tumor recurrence or resistance to treatment often arises due to tumor heterogeneity. There is a need to develop smart biopsy devices: 1) to collect biopsies from multiple tumor cores; 2) to identify locations of the biopsies; 3) to maintain physical characteristics of tumor on the extracted samples; 4) to be used under current image-guided practices. We propose to further develop a prototype of multi-core biopsy device (MCBD) that we have already developed to enable collection of multi-core tissue samples in a volume around the biopsy needle. We expect to provide prototype device that will enable rapid acquisition and preservation of multiple tissue cores under electromagnetic position navigation. If successful, the project will have substantial commercial potential as the proposed device will facilitate the acquisition of multiple tissue cores in any tissue type and with any needle size and will improve the quality of biomolecular analysis by better preservation and handling of the tissue samples. This research has substantial effect on public health as it can reduce healthcare cost by shortening image guided biopsy procedures, and it can improve patient management by better matching between tumor type and specific therapy based comprehensive evaluation of the tumor and better tissue preservation.