NIDCD Core for Clinical Research and Care

NIDCD临床研究和护理核心支持以下NIDCD项目： 1 Z01-DC-000016核因子-kappaB在影响人类沟通的肿瘤分子发病机制和治疗中的作用 1 Zia DC000039综合征性和非综合征性耳聋基因鉴定 1 Zia DC000046人类沟通障碍的遗传学研究 1人遗传性耳聋的Zia DC000060分子分析 1 Zia DC000064听力和平衡障碍临床分析 1头颈癌中ZIA-DC-000073信号和转录因子网络的相互作用 1头颈癌ZIA-DC-000074基因组学和蛋白质组学研究 1个ZIA-DC-000082神经病学项目 1-ZIA-DC-000087的特性及其增强头颈癌抗肿瘤免疫应答的研究 1-ZIA-DC-000088成人内耳听力恢复的细胞和分子机制 1-ZIA-DC-000090机制及顺铂治疗头颈癌的优化组合 核心支持的NIDCD协议包括： Oh93-DC-0016-非综合征遗传性耳聋基因图谱：印度/巴基斯坦方案 97-DC-0180-遗传性耳聋的遗传分析 01-DC-0099-NIDCD头颈外科分会临床研究方案评价 01-DC-0228-前庭导水管扩大所致听力损害的临床和分子分析 01-DC-0229-遗传性听力和平衡障碍的遗传分析 17-DC-0138-顺铂和他汀类药物耳毒性 18-DC-0051-NIDCD生物检疫协议 NIDCD临床研究和护理核心每年支持3000多个门诊评估。耳鼻咽喉科核心医生每年要做50-100例大手术。在高级临床助理期间，工作人员指导医学生。耳鼻咽喉科医生科学家职业发展计划通过强迫症协调，在过去的一年里招募了两名候选人。 选定的协作报告： Gochuico BR，Ziegler SG，Ten NS，Balanda NJ，Mason CE，Zumbo P，Evans CA，Van Waes C，Gahl WA，Malicdan MCV。一种全面、多学科、精确的医学方法，以发现对未诊断的、进行性的、纤维炎症疾病的有效治疗方法。Transl Resl 2020 Jan；215：31-40。DOI：10.1016/j.trsl.2019.08.008.EPub 2019年8月28日。 国王Ka，安萨里·G，Panackal AA，Zalewski C，Anjum S，Bennett Je，Beri A，Kim HJ，Hammoud D，布鲁尔CC，威廉姆森PR。非HIV既往健康患者中隐球菌性脑膜脑炎的听力学和耳科并发症。Otol Neurotol。2019年7月；40(6)：e657-e664。DOI：10.1097/MAO.0000000000002242.

The NIDCD Core for Clinical Research and Care supports the following NIDCD projects: 1 Z01-DC-000016 NF-kappaB in the molecular pathogenesis and therapy of Neoplasms Affecting Human Communication 1 ZIA DC000039 Identification of Genes Causing Syndromic And Nonsyndromic Hearing Impairment 1 ZIA DC000046 Genetic Studies of Human Communications Disorders 1 ZIA DC000060 Molecular Analysis Of Human Hereditary Deafness 1 ZIA DC000064 Clinical Analysis Of Disorders Of Hearing And Balance 1 ZIA-DC-000073 Signal and Transcription Factor Network Interactions in Head and Neck Cancer 1 ZIA-DC-000074 Genomics and Proteomics of Head and Neck Cancer 1 ZIA-DC-000082 Neurotology Program 1 ZIA-DC-000087 Characterization & Enhancement of Anti-tumor Immune Responses in Head & Neck Cancer 1-ZIA-DC-000088 Cellular and Molecular Pathogenesis of Hearing Restoration in Adullt Inner Ear 1-ZIA-DC-000090 Mechanisms and Optimal Combination of Cisplatin Chemotherapy for Head and Neck Cancer The NIDCD protocols supported by the core include: Oh93-DC-0016 - Nonsyndromic Hereditary Hearing Impairment Gene Mapping: India / Pakistan Protocol 97-DC-0180 - Genetic Analysis of Human Hereditary Hearing Impairment 01-DC-0099 - Evaluation for NIDCD Head and Neck Surgery Branch Clinical Research Protocols 01-DC-0228 - Clinical and Molecular Analysis of Hearing Impairment Associated with Enlarged Vestibular Aqueducts (EVA) 01-DC-0229- Genetic Analysis of Hereditary Disorders of Hearing and Balance 17-DC-0138 - Cisplatin and statins in ototoxcity 18-DC-0051 - NIDCD Biospecimens protocol The NIDCD Core for Clinical Research and Care supports over 3,000 outpatient clinic evaluations per year. Core otolaryngologists perform 50-100 major surgical cases annually. Staff mentor medical students during senior clinical clerkships. The Otolaryngolist Surgeon Scientist Career Development Program coordinated through the OCD, recruited two candidates in the past year. Selected Collaborative Reports: Gochuico BR, Ziegler SG, Ten NS, Balanda NJ, Mason CE, Zumbo P, Evans CA, Van Waes C, Gahl WA, Malicdan MCV.A comprehensive, multidisciplinary, precision medicine approach to discover effective therapy for an undiagnosed, progressive, fibroinflammatory disease Transl Res. 2020 Jan;215:31-40. doi: 10.1016/j.trsl.2019.08.008. Epub 2019 Aug 28. King KA, Ansari G, Panackal AA, Zalewski C, Anjum S, Bennett JE, Beri A, Kim HJ, Hammoud D, Brewer CC, Williamson PR. Audiologic and Otologic Complications of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Patients. Otol Neurotol. 2019 Jul;40(6):e657-e664. doi: 10.1097/MAO.0000000000002242.