Core D: Neuropathology Core

摘要-核心D：神经病理学核心 神经病理学核心(NC)将利用长期积极招聘密歇根大学(U- M)脑库和35年以上阿尔茨海默病(AD)患者的临床特征 研究人员将推进密歇根州ADRC的中心主题：识别、理解和调节非β- 淀粉样蛋白导致AD和相关痴呆(ADRD)患者的脑功能障碍和神经退行性变。 全国委员会的总体目标是促进对痴呆症生物学机制的创新研究，方法是 为密歇根州立大学的研究人员提供必要的试剂、专业知识和技术 大学和韦恩州立大学，以及全国各地的ADRC和调查人员。ADRD的研究 将由NC、临床核心、生物标记核心和数据管理和 统计核心，用于收集和正确描述尸检材料和相关的宰前材料 来自ADRC参与者的生物标本和临床数据。全国委员会将提供尸检材料和其他 向调查人员提供生物检疫，同时遵循2014年NIA制定的最佳实践指南 对脑组织和生物制品进行评估、储存和分配的生物制品工作组。 利用北卡罗来纳州研究人员在神经退行性蛋白病方面的不同专业知识和高含量 自动显微镜共享资源，NC还将促进对生物学的创新研究 通过提供必要的试剂、专业知识和获得技术来研究痴呆症的机制 调查人员。为了实现这些目标，NC将追求以下目标：1)发展和保持大脑 具有良好特性的冷冻和固定组织的银行，2)提供准确、详细和标准化的 神经病理评估，3)分发储存的组织和生物标本，4)提供神经病理数据 给国家阿尔茨海默氏症协调中心(NACC)，5)支持研究AD及其相关的研究人员 通过提供获得创新技术的途径来治疗痴呆症，并对受训人员进行神经病理学方面的教育 痴呆症的评估。通过这些目标，全国委员会将极大地促进基础和翻译研究 痴呆症患者，扩大积极参与这项工作的研究社区，帮助建立新的 为未来的发现而合作。

ABSTRACT – CORE D: NEUROPATHOLOGY CORE The Neuropathology Core (NC) will capitalize on the longstanding, actively recruiting University of Michigan (U- M) Brain Bank and more than 35 years of patient clinical characterization by Alzheimer’s disease (AD) researchers to advance the Michigan ADRC's central theme: to identify, understand and modulate the non-β- amyloid factors contributing to brain dysfunction and neurodegeneration in AD and related dementias (ADRD). The overall goal of the NC is to facilitate innovative research into the biological mechanisms of dementia by providing essential reagents, expertise, and access to technologies for investigators at U-M, Michigan State University, and Wayne State University, and to ADRCs and investigators across the country. Studies of ADRD will be facilitated by the integrated efforts of the NC, Clinical Core, Biomarker Core, and Data Management and Statistical Core to collect and properly characterize post-mortem material and associated antemortem biospecimens and clinical data from ADRC participants. The NC will provide postmortem material and other biospecimens to investigators while following the best practice guidelines delineated by the 2014 NIA biospecimen task force for the evaluation, banking and distribution of brain tissue and biospecimens. Leveraging the diverse expertise of NC investigators in neurodegenerative proteinopathies and a high-content automated microscopy shared resource, the NC also will facilitate innovative research into the biological mechanisms of dementia by providing essential reagents, expertise, and access to technologies for investigators. To accomplish these goals, the NC will pursue the following aims: 1) grow and maintain a brain bank with well-characterized frozen and fixed tissue, 2) provide accurate, detailed, and standardized neuropathological evaluation, 3) distribute banked tissue and biospecimens, 4) contribute neuropathologic data to the National Alzheimer’s Coordinating Center (NACC), 5) support researchers studying AD and related dementias by providing access to innovative technologies, and 6) educate trainees about the neuropathologic assessment of dementia. Through these aims, the NC will greatly facilitate basic and translational studies of the dementias, expand the research community actively engaged in this work, and help build new collaborations for future discoveries.