Biostatistics

摘要：生物统计学共享资源 生物统计学共享资源（BIOS）为LCCC教师提供基础，临床， 翻译和人口科学频谱经验丰富的工作人员和公认的国家领导人， 统计建模和分析。该中心的科学广度需要广泛的专业知识 在BIOS中可用，包括例如：人口科学、心理测量分析、临床试验设计 和分析，基础实验科学以及“大数据”组学。这个范围需要一个核心， 从小型企业到大型企业，几乎所有成员都可以访问“前端”的实验设计 审判鼓励通过每周步行进入位于Lineberger中庭中心的诊所， 各级教师和学生可以在项目开始时讨论项目。硕士和博士水平全职 BIOS SR工作人员经营这家诊所，也有一个传统的预约系统， 定义的问题。该团队由高级生物统计学家提供支持，他们具有来自 公共卫生学院国际公认的生物统计学系。这些领导人还担任 方案审查委员会和数据和安全性监查委员会。高级教师充分参与 LCCC研究作为合作者和研究人员的方法，例如在临床生物统计学PO1 试验方法开发。此外，教职员工都鼓励研究生的参与 谁有机会从事教师和同行在统计审查的一部分，他们自己的培训下， 学院级高级统计员的指导。该设施是LCCC专用的SR， 在2019财政年度超过100名教师。BIOS要求239，374美元，约占总额的20% 这个高度补贴的设施的运营成本由每年LCCC贡献约100万美元的BIOS维持， 在过去的五年里，我们一直是多项赠款和出版物的关键合作伙伴，从拉希德博士对 诺贝尔奖获得者阿齐兹·桑卡尔关于DNA修复过程的昼夜节律的工作与谭博士为谭博士设计的 Song的护理人员对患者症状的管理项目。

ABSTRACT: BIOSTATISTICS SHARED RESOURCE The Biostatistics Shared Resource (BIOS) provides access for LCCC faculty across the basic, clinical, translational and population science spectrum to an experienced staff and recognized national leaders in statistical modeling and analysis. The Center’s breadth of science requires a broad range of expertise available in BIOS and includes for example: population sciences, psychometric analysis, clinical trial design and analysis, basic experimental science as well as “big data” –omics. This range requires a core that can be accessed by virtually all members on the “front end” for experimental design from small undertakings to large trials. Access is encouraged through a weekly walk in clinic centrally located in the Lineberger atrium where faculty and students at all levels can discuss projects at their inception. The masters and doctoral level full time BIOS SR staff operate this clinic and there is also a traditional appointment system for researchers with defined problems. This team is supported by senior biostatisticians with a wide range of expertise from the School of Public Health’s internationally recognized Biostatistics Department. These leaders also serve on the Protocol Review Committee and the Data and Safety Monitoring Committee. Senior faculty are fully engaged in LCCC research as collaborators and researchers in methods, for example in the Biostatistics PO1 in clinical trials methods development. In addition both staff and faculty encourage the participation of graduate students who have the opportunity to engage faculty and peers in statistical review as part of their own training under the guidance of the senior faculty-level statisticians. This facility is a LCCC exclusive SR and was well used by over 100 faculty in fiscal year 2019. BIOS requests $239,374 which is approximately 20% of the total operating costs for this highly subsidized facility sustained by an annual LCCC contribution of ~$1M BIOS has been a key partner in multiple grants and publications over the prior five years, from Dr Rashid’s analysis of Nobel Laureate Aziz Sancar’s work on circadian timing of DNA repair processes to Dr Tan’s design for Dr Song’s project in caregiver’s management of patient symptoms.