Rat Resource and Research Center

摘要(总体) 大鼠资源与研究中心(RRRC)的使命是为生物医学研究人员提供 大鼠模型、胚胎干细胞、相关试剂、方案、信息、支持和服务 他们的研究。RRRC通过导入、存储和分发大量 老鼠品系/种群。它确保有价值的模型被保存下来，并提供给感兴趣的调查人员， 允许研究人员满足NIH对资源共享的要求，将个人调查人员从 动物分布的负担，并确保模型通过严格的遗传质量控制和 健康监测，以促进实验的严密性和重复性。基因组编辑的最新进展 技术正在促进在大鼠身上进行复杂的基因修改的能力，以便研究两者 正常的生物过程和疾病状态。因此，大鼠模型的数量和大鼠的数量 使用大鼠模型进行生物医学研究的研究人员正在增加，RRRC作为仅有的集中的 世界各地的存储库将继续在归档和分发这些新模型方面发挥关键作用。至 改善精子库功能，应用研究优化精子冷冻和体外保存方法 将对大鼠进行受精，并不断努力提炼、产生和表征新的基因 将进行研究界需要的修改后的大鼠模型。要扩展的广泛用途， RRRC，我们将继续为社会提供咨询服务，并将在 模型生成、模型表征、菌落管理、超低温保存和再衍生等领域。 通过向研究老鼠的调查人员提供可获得的专业知识，并通过扩大我们可用的材料 和服务，RRRC将继续为使用RAT的调查人员提供急需的“一站式”资源 在生物医学研究方面。

Abstract (Overall) The mission of the Rat Resource and Research Center (RRRC) is to provide biomedical investigators with the rat models, embryonic stem cells, related reagents, protocols, information, support and services that will facilitate their research. The RRRC serves as a unique repository by importing, storing and distributing a large number of rat strains/stocks. It assures that valuable models are preserved and made available to interested investigators, allows researchers to satisfy NIH requirements for resource sharing, relieves individual investigators from the burden of animal distribution and ensures that models are maintained with rigorous genetic quality control and health monitoring to promote experimental rigor and reproducibility. Recent advances in genome editing technologies are facilitating the ability to perform sophisticated genetic modifications in rats in order to study both normal biological processes and disease states. As a result, the number of rat models and the number of investigators using rat models for biomedical research is increasing and the RRRC, as one of the only centralized repositories in the world will continue to serve a critical role for archiving and distributing these new models. To improve repository functions, applied research to optimize methods for sperm cryopreservation and in vitro fertilization in the rat will be undertaken and ongoing efforts to refine, generate and characterize new genetically modified rat models needed by the research community will be performed. To expand the broad utility of the RRRC, we will continue to serve as consultants to the community and we will increase our fee-for-services in the areas of model generation, model characterization, colony management, cryopreservation and rederivation. By providing accessible expertise to investigators working with rats and by expanding our available materials and services, the RRRC will continue to serve as a much-needed “one stop” resource for investigators using rats in biomedical research.