University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)

项目摘要--总体构成部分 南加州大学南加州大学诺里斯综合癌症中心一直在 自1973年以来，作为NCI指定的综合癌症中心，一直得到资助。NCCC有着丰富的传统 作为癌症研究的主要区域和国际资源， 教育、社区推广和参与，以及以患者为中心的肿瘤学护理。我们的愿景是减少 癌症给所有人带来的负担。NCCC的中心优先事项是服务于与癌症相关的独特需求 我们的多元文化集水区洛杉矶县(LAC)。为了实现这一目标，我们的187个正式会员组成 合作团队，并被组织成五个有影响力的研究项目，由六个有价值的共享 资源(SR)。NCCC的癌症研究培训和教育协调(CRTEC)计划是 为下一代杰出的癌症科学家创造了一个多样化的渠道 和临床医生。NCCC社区外联和参与办公室(COE)是通过 我们了解、参与并服务于我们集水区内服务不足的社区的需求。我们的 美国第四大多元化城市的地理位置为NCCC提供了在研究方面领先的机会 这解决了不同社区和特殊人群之间的癌症负担和差异。的确， NCCC的特点是在招募不同人群进行临床试验方面取得了非凡的成功，其中包括少数族裔 占介入治疗收益的61%以上。此应用程序请求：1)支持 5个互动研究计划；2)部分支持6个SR和1个开发中的临床前SR，提供 技术、服务和科学咨询，将增强成员的互动和生产力；3) 支持领导、规划和评估；4)支持发展基金，以促进追求新的 优先事项，加强科学，探索新的合作和技术，所有这些都与新的NCCC保持一致 战略计划；5)支持癌症中心管理；6)支持集中科学监督 癌症临床试验。会员目前持有总计1.013亿美元的赠款(直接成本)，其中3770万美元来自NCI 并撰写了具有里程碑意义的出版物，代表了高度的方案内(26%)、方案间 (25%)和多机构(45%)癌症研究。癌症中心支持赠款继续提供资金 (CCSG)将使我们能够增强我们在基础、人口和临床科学方面的优势，并促进 发现并将其转化为患者和不同社区的直接利益。

PROJECT SUMMARY – Overall Component The USC Norris Comprehensive Cancer Center at the University of Southern California (NCCC) has been continuously funded as an NCI-designated Comprehensive Cancer Center since 1973. NCCC has a rich tradition of collaborative research and serves as a major regional and international resource for cancer research, education, community outreach and engagement, and patient-centered oncology care. Our vision is to reduce the burden of cancer for all people. A central priority for NCCC is to serve the unique cancer-related needs of our multicultural catchment area, Los Angeles County (LAC). To achieve this goal, our 187 full members form collaborative teams and are organized into five impactful Research Programs served by six valuable Shared Resources (SRs). NCCC’s Cancer Research Training and Education Coordination (CRTEC) programs are part of the fabric of these efforts, creating a diverse pipeline for the next generation of exceptional cancer scientists and clinicians. The NCCC Office of Community Outreach and Engagement (COE) is the primary vehicle by which we understand, engage, and serve the needs of the underserved communities in our catchment area. Our geographic location in the 4th most diverse city in the nation affords opportunities for NCCC to lead in research that addresses cancer burdens and disparities among diverse communities and special populations. Indeed, NCCC is distinguished by exceptional success in recruiting diverse populations to clinical trials, with minorities accounting for more than 61% of interventional therapeutic accruals. This application requests: 1) support for five interactive Research Programs; 2) partial support for six SRs and one Developing Preclinical SR that provide technologies, services, and scientific consultation that will enhance member interaction and productivity; 3) support for Leadership, Planning, and Evaluation; 4) support for Developmental Funds to foster pursuit of new priorities, strengthen science, and explore new collaborations and technologies, all aligned with the new NCCC Strategic Plan; 5) support for Cancer Center Administration; and 6) support centralized scientific oversight of cancer clinical trials. Members currently hold grants totaling $101.3M (direct costs) with $37.7M from NCI and have authored landmark publications representing high intra-programmatic (26%), inter-programmatic (25%) and multi-institutional (45%) cancer research. Continued funding from the Cancer Center Support Grant (CCSG) will allow us to build on our strengths in basic, population, and clinical sciences, and to facilitate discovery and its translation into direct benefit to patients and diverse communities.