Yale Center for Metabolic Phenotyping in Live Models of Obesity and Diabetes

耶鲁大学MPMOD的首要目标是为校外研究人员提供独特的代谢途径， 耶鲁大学MPMOD提供的表型分析服务，并使他们能够利用小鼠遗传学的力量 最大限度地发挥其代谢表型肥胖和糖尿病小鼠模型的潜力。耶鲁大学MPMOD 由三个高度互动的核心组成，这些核心在以下方面有着良好的合作记录（>20年）： 密切协调：1）耶鲁MPMOD行政核心监督耶鲁MPMOD的运作， 促进与其他MPMOD中心和MPMOD协调单位的研究， 方法，并通过Yale MPMOD核心和访问Yale MPMOD动物核心和耶鲁MPMOD表型核心，2）耶鲁MPMOD动物核心提供 用于协调接收、筛选和监测来自外部研究者的小鼠的集中设施，以及3） Yale MPMOD Phenotyping Core使Yale MPMOD客户能够获得独特的代谢表型 为他们提供表征特定小鼠模型中代谢变化的方法的服务 复杂代谢疾病的研究。耶鲁大学的具体目标 MPMOD将：1）服务于美国学术研究界，研究他们的小鼠糖尿病和肥胖症 通过提供活体小鼠的代谢、生理和行为表型以及专家建议， 在小鼠模型中，实验设计、数据分析和数据解释的成本相似，无论是内部还是外部， 在耶鲁大学之外没有偏见，并合作提供广泛的测试和专家建议，同时避免 不必要的重叠，2）建立一个耶鲁MPMOD充满活力的计划，这将与其他国家 MPMOD和MPMOD协调单位，以促进美国生物医学领域的健康公平和多样性 研究企业通过支持代表性不足的少数民族研究人员在生物医学研究中取得成功， 糖尿病和肥胖症领域，通过资源，如测试服务，试点资金，专家咨询， 实验设计，和/或在耶鲁大学MPMOD短期实习学习测试技术，3）促进严谨性 通过以下方式提高研究的可重复性：a）开发和共享经验证的活小鼠表型分析方案; B） 提供由专家进行的高难度实验测试，具有高度的标准化和质量 控制，否则将无法进行或负担不起的PI;以及c）共享技术， 为实验方法和数据分析中的黄金标准方法提供基于网络的工具，4）。发展 与客户共享的复杂数据（包括元数据）的标准化数据格式和存储准则 并酌情采用唯一的研究资源标识符（RRID），数字对象 标识符（DOI）和其他由DKNet指导的最佳实践。

The overarching goal of the Yale MPMOD is to provide extramural investigators access to the unique metabolic phenotyping services provided by the Yale MPMOD and empower them to harness the power of mouse genetics to its fullest potential to metabolically phenotype their mouse models of obesity and diabetes. The Yale MPMOD consists of three highly interactive Cores that have an established (>20 yr) track record of working together in close harmony: 1) The Yale MPMOD Administrative Core oversees the operation of the Yale MPMOD, facilitates research with the other MPMOD Centers and the MPMOD Coordinating Unit to standardize key methodologies, and coordinates the efficient workflow through the Yale MPMOD cores and access to the Yale MPMOD Animal Core and the Yale MPMOD Phenotyping Core, 2) The Yale MPMOD Animal Core provides a centralized facility for coordinating receiving, screening and monitoring mice from outside investigators and 3) The Yale MPMOD Phenotyping Core empowers Yale MPMOD clients with access to unique metabolic phenotyping services that provides them with the means to characterize the metabolic changes in their particular mouse models of complex metabolic disease using established state-of-the-art methodology. The Specific Aims of the Yale MPMOD are to: 1) serve the US academic research community to study diabetes and obesity in their mouse models by providing metabolic, physiologic, and behavioral phenotyping on live mice, as well as expert advice in mouse models, experiment design, data analysis, and data interpretation at similar cost whether inside or outside Yale without bias and, and collaborate to provide a wide array of tests and expert advice while avoiding unnecessary overlap, 2) Establish a Yale MPMOD Vibrant Program, which will work with the other national MPMODs and the MPMOD Coordinating Unit to promote health equity and diversity in the US biomedical research enterprise by supporting underrepresented minority investigators to succeed in biomedical research in the areas of diabetes and obesity, via resources such as test services, pilot funding, expert advice on experimental design, and/or short internships at the Yale MPMOD to learn test technologies, 3) Promote rigor and reproducibility in research by: a) developing and sharing validated protocols for phenotyping live mice; b) providing difficult experimental tests conducted by experts with a high degree of standardization and quality control, to PIs who would otherwise not be able to conduct or afford them; and c) sharing technologies and providing web-based tools for gold-standard approaches in experimental methods and data analysis, 4). Develop standardized data formats and storage guidelines for complex data, including metadata, for sharing with clients and the public as appropriate, and employ unique Research Resource identifiers (RRID), Digital Object Identifiers (DOI), and other best practices directed by DKNet.