rTMS in alleviating Pain and Co-morbid symptoms in GWVI

摘要 头痛(HA)、肌肉和关节疼痛和抑郁是最常见的几种 在1990-1991年波斯湾战争(GW1)中服役的军事人员出现衰弱症状。 在海湾战争退伍军人中发现了类似HA的偏头痛和弥漫性身体疼痛 被诊断出患有海湾战争退伍军人疾病(GWVI)。同样，抑郁症也有很高的相关性。 慢性疼痛患者和与GWVI相关的GWV患者的发病率(50%) HA，以及身体肌肉和关节疼痛状况(GWVI-HAP)。重复经颅磁 刺激(RTMS)为GWVI-HAP提供了一种有效的非侵入性治疗选择。我们的 GWVI国防部创新治疗评价奖资助的初步研究 研究表明，在运动皮质进行短程(4次)rTMS可以显著 将GWI-HAP症状减少最多两个月。这项多中心临床试验研究旨在进一步： 1)有效治疗GWI-HAP和抑郁症的远期疗效；2)评估部位 治疗疼痛和抑郁的特异性。 好了！

Abstract Headaches (HA), muscle and joint pain and depression are some of the most common debilitating symptoms in military personnel served in the 1990-1991 Persian Gulf War (GW1). Migraine like HA and diffuse body pain were detected in 64% of Gulf War Veteran (GWV) diagnosed with Gulf War Veterans’ Illnesses (GWVI). Likewise, depression carries a very high co- morbid prevalence (50%) in patients with chronic pain, and in GWV with GWVI related chronic HA, and body muscle and joint pain conditions (GWVI-HAP). Repetitive transcranial magnetic stimulation (rTMS) offers an effective non-invasive treatment option for GWVI-HAP. Our preliminary study funded by the DOD Innovation Treatment Evaluation Award for GWVI demonstrated that a short course (4 sessions) of rTMS at the motor cortex could significantly reduce GWI-HAP symptoms up to two months. This multi-center clinical trial study aims to further: 1) valid the long-term efficacy of the treatment for GWI-HAP and depression; and 2) assess site specificity of the treatment for both pain and depression. !