Methods for Selective Organic Synthesis based on Ionic Catalysts

项目摘要 本研究计划的主要目标是开发催化对映体。 基于过渡金属和手性阴离子催化的转化将被广泛应用 适用于制备具有治疗作用的有机分子。朝向这个方向 C-O、C-N和C-卤素对映体选择性构筑的新反应 债券是被提议的。特别强调的是发展的方法，以 选择性地引入氟和含氟官能团。 此外，生成或使用可用构建块的反应，如 烯烃和硼酸将成为目标。这些方法将利用新的催化剂 基于金(III)络合物和磷酸基手性阴离子的平台，用于 含氟砌块和杂环的结构此外， 我们将研究这些反应的机理基础，重点是 揭示非共价相互作用在实现选择性方面的作用。因此，我们 预计该计划将为合成化学家和生物医学研究人员提供 使用其他工具(反应、催化剂、配体等)用于分子合成和用于 单一对映体的构建，以及为进一步开发提供原则 和应用程序。

Project Summary The major goal of this research program is to develop catalytic enantioselective transformations based on transition metal and chiral anion catalysis that will be broadly applicable to the preparation of therapeutically relevant organic molecules. Towards this end, new reactions for the enantioselective construction of C-O, C-N and C-halogen bonds are proposed. Particular emphasis is placed on the development of methods for the selective introduction of fluorine and fluorine-containing functional groups. Additionally, reactions that generate or employ available building blocks, such as alkenes and boronic acids, will be targeted. These methods will leverage new catalyst platforms, based on gold(III) complexes and phosphoric acid-based chiral anions, for the construction of fluorinated building blocks and heterocycles Additionally, the mechanistic underpinnings of these reactions will be studied, with a focus on uncovering the role of non-covalent interactions in achieving selectivity. Thus, we anticipate that this program will provide synthetic chemists and biomedical researchers with additional tools (reactions, catalysts, ligands etc.) for molecular synthesis and for single enantiomer construction, as well as provide principles for further development and application.