兴奋剂选择的药理学-猫眼课题宝

兴奋剂选择的药理学

批准号：

10585535

负责人：

Matthew L Banks

金额：

$34.93万

依托单位：

VIRGINIA COMMONWEALTH UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2023

资助国家：

美国

项目状态：

未结题

起止时间：

2023-04-15 至 2028-02-29

来源：

https://reporter.nih.gov/project-details/10585535

关键词：

Acceleration Admission activity Agonist Animals Attenuated Basic Science Behavior Behavioral Biological Assay Biosensor CHRM1 gene Cessation of life Cholinergic Agonists Clinical Clinical Data Clinical Trials Cocaine Cocaine Abuse Cocaine use disorder Data Decision Making Development Dopamine Dose Drug Addiction Drug Use Disorder Effectiveness Experimental Designs Failure Female Food Funding Human Laboratory Animals Laboratory Study Measures Mediator Methamphetamine Methamphetamine use disorder Microdialysis Modeling Monitor Muscarinic Acetylcholine Receptor Muscarinics National Institute of Drug Abuse Negative Reinforcements Neurobiology Neurotransmitters Nucleus Accumbens Pharmaceutical Preparations Pharmacology Pharmacotherapy Prefrontal Cortex Procedures Public Health Publications Rattus Research Research Subjects Self Administration Series Serotonin Agonists Signal Transduction Source Stimulant System Testing Time United States Food and Drug Administration United States National Institutes of Health Work antagonist effectiveness evaluation experimental study human subject in vivo male methamphetamine abuse non-drug overdose death pharmacologic pre-clinical reinforcer social stimulant abuse stimulant misuse stimulant use disorder therapeutic candidate

中文摘要

翻译

这个新的R 01应用程序提出了一系列系统的实验，重点是药物选择程序，雄性和雌性大鼠评价毒蕈碱乙酰胆碱受体（mAChR）1激动剂VU 0364572作为用于治疗可卡因和甲基苯丙胺使用障碍的候选药物。本申请成立于前提是人类的兴奋剂使用障碍可以使用药物与食物的临床前试验进行研究，选择模型的临床方面的行为分配不当和决策之间的同时可用的药物和替代的非药物治疗剂。我们建议确定1）VU 0364572对可卡因-食物和可卡因-社会选择，2）VU 0364572对甲基苯丙胺-食物的影响，甲基苯丙胺-社会选择，以及3）VU 0364572对丘脑核和前额叶皮层的影响使用dLight释放多巴胺。

英文摘要

This new R01 application proposes a systematic series of experiments focused on drug-choice procedures in male and female rats to evaluate the muscarinic acetylcholine receptor (mAChR)1 agonist VU0364572 as a candidate medication for treatment of cocaine and methamphetamine use disorder. This application is founded on the premise that stimulant use disorder in humans can be studied using preclinical assays of drug-vs-food choice that model clinical aspects of behavioral misallocation and decision making between concurrently available drugs and an alternative nondrug reinforcer. We propose to determine 1) VU0364572 effects on cocaine-food and cocaine-social choice, 2) VU0364572 effects on methamphetamine-food and methamphetamine-social choice, and 3) VU0364572 effects on nucleus accumbens and prefrontal cortex dopamine release using dLight.

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