Corneal Biomechanics in Ocular Disease

摘要 拟议延长的目的是增加一个纵向组成部分， 生成风险模型以预测眼部疾病的进展， 在基线处建立的指标。角膜对应力的贡献的新度量是 在基线时发展，代表对不对称生物力学的长期适应 我们提出的圆锥角膜的性质将预测随访期间的进展。 进展模型中将包括角膜可压缩性的额外指标。在 糖尿病无视网膜病变，我们认为巩膜硬度将预测 糖尿病视网膜病变在随访期间，增加巩膜硬度是一个 长期高血糖的累积指标，我们归因于非- 巩膜中的酶交联。血红蛋白A1c将作为离散的 高血糖指标。最后，我们建议增加弹性和粘弹性生物力学 高眼压治疗研究的风险模型的指标，以预测 从高眼压转为青光眼。弹性参数包括角膜硬度 和巩膜硬度，并且粘弹性参数是角膜滞后。一旦完成， 这些风险模型可以作为新的工具应用于临床， 多种眼部疾病 .

ABSTRACT The purpose of the proposed renewal is to add a longitudinal component for the purpose of generating risk models to predict progression in ocular diseases that include biomechanical metrics established at baseline. A novel metric of Corneal Contribution to Stress was developed at baseline that represents long-term adaptation to asymmetric biomechanical properties in keratoconus which we propose will predict progression over the follow-up period. An additional metric of cornea compressibility will be included in the progression model. In Diabetes without retinopathy, we propose that scleral stiffness will predict development of diabetic retinopathy during the follow-up period, and that increased scleral stiffness is a cumulative indicator of long-term hyperglycemia which we attribute to the formation of non- enzymatic cross-links in the sclera. Hemoglobin A1c will be included in the model as a discrete indicator of hyperglycemia. Finally, we propose to add elastic and viscoelastic biomechanical metrics to the risk model from the Ocular Hypertension Treatment Study to predict the conversion from ocular hypertension to glaucoma. Elastic parameters include corneal stiffness and scleral stiffness, and the viscoelastic parameter is corneal hysteresis. Once completed, these risk models can be translated to the clinic as new tools to aid in the management of multiple ocular conditions. .