Preventing Infections and Antimicrobial Resistance in the Aging Population: Translational Research and Training Program

摘要 在医院和养老院(NHS)等机构中，虚弱的老年人处于特别高的水平 结果不佳的风险。将研究成果转化为临床实践，特别是在NHS，是 很有挑战性。教育和培训一组多学科的初级调查人员是设计 基于证据的随机研究，以测试创新的模式和做法，以减少感染和 NH环境中的抗菌素耐药性。为了继续她久负盛名的翻译研究。 密歇根大学阿曼达·桑福德·希基内科教授洛娜·莫迪是 提交此K24续订建议书。莫迪博士的职业目标是在国内和国际上发展一种 在易感人群中预防感染的公认计划。她将通过以下方式实现这一目标 开展以患者为中心的研究，以改善传染病的结果并减少 在脆弱的老年人口中传播细菌和病毒感染，并通过教育和培训 学员组成的多学科小组。她职业生涯的大部分时间都致力于 以病人为中心的研究。在过去的5年里，她发表了90篇论文，其中6篇 关于职业发展和工作与生活的平衡。53人是第一作者或资深作者(90人中的59%) 59个出版物是导师/学员合作(占90个出版物的66%)。她的几位导师已经收到了 职业发展奖，包括GEMSSTAR、K奖和机构职业发展补助金 导致独立的学术生涯和终身教职的职位。她已经建立了源源不断的 研究资助和有效的指导，并在整个指导过程中继续合作 事业。 莫迪博士的研究汇集了老年病学和老龄化研究、微生物学和传染病方面的专业知识 疾病、流行病学、结果研究、护理和其他。她在减少感染方面的工作和 脆弱人群中的抗菌素耐药性源于最初由NIA，AHRQ， CDC、T·富兰克林·威廉姆斯奖学金(现在称为GEMSSTAR)和哈特福德基金会。几个 目前得到资助的赠款将作为这项赠款提案的平台，包括由 美国国立卫生研究院、AHRQ、弗吉尼亚州和卡恩基金会。这些研究将产生丰富的数据集和银行微生物 将用于教育和培训以患者为中心的研究指导对象，并扩展到分子 流行病学和基于社区的参与性研究。支持教育、培训和 开发项目包括密歇根大学医学院、弗吉尼亚州安娜堡医疗系统、密歇根大学 密歇根大学临床与健康研究所内科、密歇根大学外科 (MICHR，UM-CTSA)、UM OAIC胡椒中心和UM公共卫生学校。

ABSTRACT Frail older adults in institutional settings such as hospitals and nursing homes (NHs) are at a particularly high risk of poor outcomes. Translation of research findings into clinical practice, particularly in NHs, is challenging. Educating and training a multidisciplinary group of junior investigators is key to designing evidence-based, randomized studies to test innovative models and practices that reduce infections and antimicrobial resistance in NH settings. In order to continue her well-established translational research, Dr. Lona Mody, Amanda Sanford Hickey Professor of Internal Medicine at the University of Michigan, is submitting this K24 renewal proposal. Dr. Mody’s career objective is to develop a nationally and internationally recognized program in infection prevention among susceptible populations. She will achieve this objective by conducting patient-oriented research that improves outcomes from infectious diseases and reduces transmission of bacterial and viral infections in a vulnerable older population and by educating and training a multidisciplinary group of mentees. The majority of her professional life has been dedicated to the conduct of patient-oriented research. During the past 5 years, she has published 90 papers, including six articles pertaining to career development and work-life balance. Fifty-three were as first or senior author (59% of 90) and 59 publications were mentor/mentee collaborations (66% of 90). Several of her mentees have received career development awards including GEMSSTAR, K awards and institutional career development grants leading to independent academic careers and tenure track positions. She has established a steady stream of research funding and effective mentorship, with continued collaboration throughout the course of mentees’ careers. Dr. Mody’s research brings together expertise in geriatrics and aging research, microbiology and infectious diseases, epidemiology, outcomes research, nursing, and others. Her work on reducing infections and antimicrobial resistance in vulnerable populations grows out of work originally funded by the NIA, AHRQ, CDC, T. Franklin Williams Scholarship (now known as GEMSSTAR), and the Hartford Foundation. Several currently funded grants will serve as the platform for this grant proposal, including ongoing work funded by NIH, AHRQ, VA, and the Kahn Foundation. These studies will yield rich datasets and banked microbes that will be utilized to educate and train mentees in patient-oriented research with extensions to molecular epidemiology and community-based participatory research. Resources supporting the education, training, and development include the University of Michigan Medical School, VA Ann Arbor Healthcare System, UM Department of Medicine, UM Department of Surgery, Michigan Institute for Clinical and Health Research (MICHR, UM-CTSA), UM OAIC Pepper Center, and the UM School of Public Health.