Center of Biomedical Research Excellence in Cardiovascular Health

项目摘要/摘要 心血管疾病(心血管疾病)，如冠状动脉疾病、心力衰竭和中风仍然是最多的 在美国，男性和女性都有一个死亡原因。心血管疾病对特拉华州人的影响远远超过 全国平均水平。心血管疾病在很大程度上是可以预防的，并与该州和地区普遍存在的风险因素有关 例如不良饮食、肥胖、缺乏运动和其他可改变的行为。除了这些风险因素外， 年龄的增长和其他慢性病的存在显著增加了心血管事件的风险 和死亡。这些慢性病在特拉华州乃至全国都很常见。 理想的心血管健康定义为没有临床表现的心血管疾病，以及最佳水平的 血压、胆固醇、血糖和体重。此外，理想的心血管健康是 与健康的行为有关，如有规律的体育活动、不吸烟和健康的饮食模式。 众所周知，不健康的心血管行为会导致结构性和/或功能性血管 改变，造成靶器官损害和损害。需要更多机械化的信息来打击 需要对心血管疾病和新的干预措施进行测试，以改善心血管健康和整体福祉。 特拉华大学心血管健康生物医学研究卓越中心的目标是 继续支持多学科研究，旨在了解 心血管健康和/或功能不良的原因和后果，并制定有效的干预措施 在这些情况下。在第一阶段，该中心成功地发展了一批人的独立研究事业 调查人员。我们将促进四名新的心血管研究人员的研究生涯 第二阶段。这些调查人员将得到一个全面的指导和职业发展计划的支持， 以及通过科布雷研究核心的基础设施。这些核心资源以及一个试点计划 新招聘的教职员工将使该中心实现更长期的可持续发展。

PROJECT SUMMARY/ABSTRACT Cardiovascular diseases (CVDs) such as coronary artery disease, heart failure, and stroke remain the number one cause of death in the U.S. for both men and women. CVDs affect Delawareans at a rate significantly above the national average. CVDs are largely preventable, and related to risk factors prevalent in the state and region such as poor diet, obesity, physical inactivity, and other modifiable behaviors. In addition to these risk factors, increasing age and the presence of other chronic conditions significantly raise the risk for cardiovascular events and death. These chronic conditions are common in the State of Delaware and indeed the nation. Ideal cardiovascular health is defined as the absence of clinically manifest CVD, along with optimal levels of blood pressure, cholesterol, blood glucose, and body weight. In addition, ideal cardiovascular health is associated with healthy behaviors such as regular physical activity, lack of smoking, and healthy eating patterns. It is well established that unhealthy cardiovascular behaviors can result in structural and/or functional vascular changes, causing target organ impairment and damage. More mechanistic information is needed to combat CVDs, and novel interventions need to be tested to improve cardiovascular health and overall wellbeing. The goal of the University of Delaware Center of Biomedical Research Excellence in Cardiovascular Health is to continue to support multidisciplinary research aimed toward understanding the mechanisms underlying the causes and consequences of poor cardiovascular health and/or function, and developing effective interventions for these conditions. In Phase I, the center successfully developed the independent research careers of a cohort of investigators. We will foster the research careers of four new cardiovascular-focused investigators during Phase II. These investigators will be supported by a comprehensive mentoring and career development program, as well as infrastructure through the COBRE Research Core. These core resources along with a pilot program and new faculty hires will position the center for longer term sustainability.