The Network for Investigation of Delirium: Unifying Scientists (NIDUS)'s 9th-13th Annual Delirium Boot Camps: A Foundation for Future Exploration

谵妄是一种严重的认知障碍，与阿尔茨海默病及相关痴呆（ADRD）有关 每年影响约260万老年人。这是一种常见的并发症，急性疾病，手术，现在， 老年人感染COVID-19。认识到谵妄研究的相对缺乏，国家研究所 NIA支持建立谵妄调查网络：团结科学家 （NIDUS），一个由来自27个机构的28名研究人员组成的跨学科合作小组， 研究和开发网络基础设施。这包括创建年度“NIDUS训练营” 会议，汇集了越来越多的国家和国际谵妄研究界， 网络和教育。训练营的目的是推进该领域的科学，并提供初级 通过模拟NIH申请审查，临床和研究讲座， 分组会议和训练营后的网络。训练营的校友提供指导：1）使用 NIDUS谵妄研究中心，测量资源和参考书目，2）向 NIDUS试点计划（13个一年期50，000美元赠款），NIA GEMSSTAR/CLINIAR，阿尔茨海默氏症 协会和其他基金会，3）参加指导网络研讨会，4）参加初级教师工作 5）向美国谵妄学会（ADS）年会提交研究摘要。作为私家侦探， 94名校友获得了46笔赠款，其中18笔（40%）是NIH资助的，并发表了265篇原创同行论文。 评论文章NIDUS已经启动了许多年轻调查人员的职业生涯，特别是训练营 校友，使他们能够启动谵妄研究的独立项目。 此应用程序的目标是支持每年一次的主题为Delirium Bootcamp会议的延续 (DBC)，以确保这一活跃的研究界的进展得以持续。第一年的主题是 谵妄与ADRD的关系。具体目标是：（1）吸引和支持年轻人 通过指导和访问NIDUS资源/网络进行谵妄研究的研究人员（2）Boost 研究人员的资助成功（3）促进谵妄研究的出版，并提供持续的 导师制，以及（4）促进初级，中级和高级研究人员之间的网络期间和之后 DBC。随着谵妄调查人员的扩大，迫切需要召开一次会议， 解决谵妄研究各个领域的前沿研究方法，包括与 ADRD，“组学”研究，机器学习和大数据，随机试验创新，动物模型和 机制研究和临床实践改进。DBC将提供无与伦比的机会， 通过互动式教学会议和深入指导，推进尖端的谵妄研究 复杂和细致入微的研究方法是最高水平和最有影响力的谵妄研究所必需的。

Delirium is a serious cognitive disorder associated with Alzheimer’s disease and related dementias (ADRD) that affects ~2.6 million older adults yearly. It is a frequent complication of acute illness, surgery and, now, of COVID-19 infection in older adults. Recognizing the relative dearth of delirium research, the National Institute for Aging (NIA) supported the establishment of the Network for Investigation of Delirium: Unifying Scientists (NIDUS), a collaborative interdisciplinary group of 28 investigators, from 27 institutions, to advance delirium research and develop network infrastructure. This included the creation of an annual “NIDUS bootcamp” conference, to bring together the growing national- and international delirium research community for networking and education. The bootcamp aims are to advance the science of the field and to provide junior investigators with intensive mentorship, through mock NIH application reviews, clinical and research lectures, breakout sessions, and post-bootcamp networking. Bootcamp alumni are provided guidance on: 1) using the NIDUS Delirium Research Hub, Measurement resources and Bibliography, 2) submitting proposals to the NIDUS Pilot Program (13 one-year $50,000 grants awarded), NIA GEMSSTAR/CLINSTAR, the Alzheimer’s Association, and other foundations, 3) attending Mentoring webinars, 4) participating in Junior Faculty Working Groups, and 5) submitting research abstracts to the American Delirium Society (ADS) Annual Meeting. As PIs, 94 alumni have received 46 grants, of which 18 (40%) were NIH-funded, and published 265 original peer- reviewed articles. NIDUS has jumpstarted the careers of many young investigators, particularly bootcamp alumni, enabling them to launch independent programs in delirium research. The goal of this application is to support continuation of a yearly, themed Delirium Bootcamp Conference (DBC), to ensure that the progress of this active research community is sustained. The first-year theme will be the inter-relationship between delirium and ADRD. The Specific Aims are to: (1) Engage and support junior investigators in delirium research through mentorship and access to the NIDUS resources/network (2) Boost the researchers’ funding success (3) Facilitate publication of delirium research and provide ongoing mentorship, and (4) Facilitate networking among junior, mid-career, and senior researchers during and after DBC. As the pool of delirium investigators expands, there is a critical need for a conference focused on addressing cutting-edge research methods in all areas of delirium research, including the relationship with ADRD, “-Omics” research, machine learning and big data, innovations in randomized trials, animal models and mechanistic research, and clinical practice improvement. The DBC will provide an unparalleled opportunity to advance cutting-edge delirium research through interactive didactic sessions and in-depth guidance on complex and nuanced research methods essential for the highest caliber and most impactful delirium research.