Novel epidemiological methods to infer the causal effects of risk factors on neuropsychiatric and cardiovascular disorders

流行病学研究将风险因素与疾病联系起来，是制定公共卫生政策的核心。由于因果关系很难从这些关联中确定，基于这些发现的公共卫生干预措施有失败的风险。我们建议开发，扩展和应用一种创新的流行病学方法，孟德尔随机化（MR），以解决危险因素与神经精神和心血管疾病之间的因果关系。

Epidemiological studies, which associate risk factors and disease, are central in informing public health policy. Because causality is difficult to ascertain from these associations, public health interventions based on these findings are at some risk of failure. We propose to develop, extend and apply an innovative epidemiological approach, Mendelian randomization (MR) to resolve the causal relationship between risk factors and neuropsychiatric and cardiovascular disorders.