Animal and Human Imaging Shared Resource

核心002 -动物和人类成像共享资源 项目总结/摘要 动物和人类成像共享资源（AHISR）一直得到癌症研究所的支持。 自2004年起获得中心支助赠款。AHISR提供科学和技术援助， 在临床前和临床环境中使用生物医学成像进行癌症研究的实验 并继续进行开发，以满足持续的需求。与前几个周期一样，AHISR仍然是一个 VICC的研究卓越的专业计划（SPORE）计划的重要组成部分，与 最近更新的具有特征成像组件的乳腺和胃肠道（GI）孢子。2018年 AHISR是获得一项新的NCI资助的联合临床成像试验资源（U24）的组成部分，该资源专注于定量 用研究性放射性药物进行癌症代谢的PET成像。此外，AHISR的专业知识 VICC和GE Health Care（GEHC）之间建立了新的合作伙伴关系， 癌症成像和放射性药物发现是一个主要的精确肿瘤学的中心支柱计划 倡议AHISR的教职员工提供最先进的成像设施，包括 在3 T和7 T下运行的先进人体MRI系统，研究专用PET/CT，超声扫描仪，以及 多模式动物成像和研究放射性药物的综合设施， 人类使用。此外，AHISR利用范德比尔特大学的机构资源 成像科学研究所（VUIIS）开发新的和改进的方法来获取信息， 解决了与癌症直接相关的研究问题。具体而言，AHISR将提供： 1.与成像科学专家合作（在核，光学，磁共振和 超声成像），用于开发和应用尖端成像协议 2.用于动物和人类成像研究的创新和新型放射性药物 3.为处理患者和动物准备的成像系统操作员和技术人员提供支持 监控和操作仪器 4.支持数据分析和定量图像分析，可针对特定应用进行定制，包括 多种模式、组织学和蛋白质组学的共同注册和整合。 AHISR将先进的设备和各种专业知识汇集到一个全面的集成系统中， 确保成像数据质量的资源，从而确保整体质量、严谨性和 研究的可重复性是最高的。

CORE 002 – ANIMAL AND HUMAN IMAGING SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The Animal and Human Imaging Shared Resource (AHISR) has been continuously supported by the Cancer Center Support Grant (CCSG) since 2004. The AHISR provides scientific and technical assistance for experiments employing biomedical imaging for the study of cancer in both the pre-clinical and clinical settings and continues to undertake developments to meet ongoing needs. As in previous cycles, the AHISR remains a critical component of VICC’s Specialized Programs of Research Excellence (SPORE) programs, with both recently renewed Breast and Gastrointestinal (GI) SPOREs having featured imaging components. In 2018, the AHISR was integral to landing a new NCI-funded co-clinical imaging trial resource (U24) focused on quantitative PET imaging of cancer metabolism with investigational radiopharmaceuticals. Furthermore, the AHISR expertise and capabilities have enabled a new partnership between VICC and GE Health Care (GEHC), where quantitative cancer imaging and radiopharmaceutical discovery are central pillar programs of a major precision oncology initiative. The faculty and staff within the AHISR provide access to state-of-the-art imaging facilities including advanced human MRI systems operating at 3T and 7T, a research-dedicated PET/CT, ultrasound scanner, and a comprehensive facility for multimodal animal imaging and research radiopharmaceuticals for animal and human use. Furthermore, the AHISR leverages the institutional resources within the Vanderbilt University Institute of Imaging Science (VUIIS) to develop new and improved methods for obtaining information that addresses research questions of direct cancer relevance. More specifically, the AHISR will provide: 1. Collaborations with expert imaging science faculty (in nuclear, optical, magnetic resonance and ultrasound imaging) for the development and application of cutting-edge imaging protocols 2. Innovative and novel radiopharmaceuticals for animal and human imaging research 3. Support for imaging system operators and technical staff who will handle patient and animal preparation and monitoring as well as operate the instruments 4. Support for data analysis and for quantitative image analysis customized to specific applications including the co-registration and integration of multiple modalities, histology and proteomics. The AHISR brings together advanced equipment and diverse expertise into a comprehensive integrated resource that ensures the quality of the imaging data, and consequently, the overall quality, rigor, and reproducibility of the studies is the highest possible.