Dedicated Quantitative Fluorescence Tomography System for Small Animal Imaging

用于小动物成像的专用定量荧光断层扫描系统

• 批准号: 7794463
• 负责人: Henry Charles Manning
• 金额: $ 35.06万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-06 至 2011-05-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794463
• 关键词: Animals; Arts; Cell physiology; Disease Progression; Fluorescence; Funding; Growth; Image; Imaging Techniques; Individual; Institution; Metric; Modality; Molecular; Optics; Physiological Processes; Research Personnel; Small Animal Imaging Systems; System; Universities; experience; fluorescence imaging; human disease; imaging modality; in vivo; interest; meetings; molecular imaging; mouse model; novel therapeutic intervention; pre-clinical; preclinical study; programs; public health relevance; response; tomography; trafficking

DESCRIPTION (provided by applicant): This application seeks funds to purchase a state-of-the-art small-animal fluorescence tomography system for users at Vanderbilt University. Non-invasive molecular imaging can be employed to quantitatively assess numerous physiological processes in vivo and is therefore an ideal metric to rapidly profile the initiation of disease, progression, and response to therapy. While the entire field of molecular imaging has experienced considerable growth over the last decade, much of this growth has come as a result of interest in preclinical imaging of small animals. Today, individual investigators and large imaging centers with an interest in preclinical molecular imaging are met with a myriad of readily available imaging hardware that spans nearly all modalities. While each imaging modality has a unique array of advantages and limitations, the optical paradigm is among the most suitable of imaging techniques for preclinical studies for numerous reasons. Fluorescence imaging in preclinical mouse models of human disease is an essential component of numerous NIH-funded programs ongoing at our institution. The proposed fluorescence tomography system will be the first of its kind at Vanderbilt University and will significantly enhance and expand current preclinical programs that utilize molecular (fluorescence) imaging as primary readouts of in vivo physiology, cell trafficking, and response to novel therapeutic interventions. PUBLIC HEALTH RELEVANCE: This application seeks funds to purchase a state-of-the-art small-animal fluorescence Tomography system for users at Vanderbilt University. Fluorescence imaging in preclinical Mouse models of human disease is an essential component of numerous NIH-funded programs Ongoing at our institution. The proposed fluorescence tomography system will be the first of its kind at Vanderbilt University and will significantly enhance and expand current preclinical programs that utilize molecular (fluorescence) imaging as primary readouts of in vivo physiology, cell trafficking, and response to novel therapeutic interventions.

描述（由申请人提供）：本申请寻求资金，为范德比尔特大学的用户购买最先进的小动物荧光断层扫描系统。非侵入性分子成像可用于定量评估体内许多生理过程，因此是快速描述疾病开始、进展和对治疗反应的理想指标。虽然整个分子成像领域在过去十年中经历了相当大的增长，但这种增长大部分是由于对小动物临床前成像的兴趣。今天，对临床前分子成像感兴趣的个体研究者和大型成像中心会遇到无数现成的成像硬件，这些硬件几乎涵盖了所有模态。虽然每种成像方式都有独特的优点和局限性，但由于许多原因，光学模式是最适合临床前研究的成像技术之一。人类疾病临床前小鼠模型的荧光成像是我们机构正在进行的许多NIH资助项目的重要组成部分。拟议的荧光断层扫描系统将是范德比尔特大学的首个此类系统，并将显著增强和扩展当前的临床前项目，这些项目利用分子（荧光）成像作为体内生理学、细胞运输和对新型治疗干预的反应的主要读数。 公共卫生关系：该申请旨在为范德比尔特大学的用户购买最先进的小动物荧光断层扫描系统。人类疾病的临床前小鼠模型中的荧光成像是我们机构正在进行的许多NIH资助项目的重要组成部分。拟议的荧光断层扫描系统将是范德比尔特大学的首个此类系统，并将显著增强和扩展当前的临床前项目，这些项目利用分子（荧光）成像作为体内生理学、细胞运输和对新型治疗干预的反应的主要读数。