Core 2: Mouse and Human Molecular Imaging

核心 2：小鼠和人类分子成像

• 批准号: 10218107
• 负责人: Henry Charles Manning
• 金额: $ 24.1万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-09 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10218107
• 关键词: Bioinformatics; Biological; Biometry; Cancer Center; Clinical Research; Colorectal Cancer; Coupled; Custom; Cyclic GMP; Data; Data Analyses; Development; Digital X-Ray; Equipment; Feasibility Studies; Functional Imaging; Future; Genomic approach; Goals; Human; Human Resources; Image; Individual; Infrastructure; Magnetic Resonance Imaging; Malignant neoplasm of gastrointestinal tract; Measures; Mission; Molecular; Molecular Probes; Mus; Optics; Pathology; Phenotype; Pilot Projects; Play; Positron-Emission Tomography; Quality Control; Radiochemistry; Research; Research Personnel; Resource Development; Resources; Role; Specimen; Tissues; Translational Research; Work; X-Ray Computed Tomography; anatomic imaging; animal imaging; base; data de-identification; gastrointestinal; imaging biomarker; imaging facilities; imaging modality; liquid biopsy; molecular imaging; novel; pre-clinical; pre-clinical research; research study; single photon emission computed tomography; tumor

PROJECT SUMMARY/ABSTRACT: Mouse and Human Molecular Imaging Core The Mouse and Human Molecular Imaging (MHMI) Core will play a central role in the translational research mission of the Vanderbilt-Ingram Cancer Center (VICC) SPORE in Gastrointestinal (GI) Cancer, providing state-of-the-art imaging resources for three projects, future pilot and feasibility studies, and developmental research. The MHMI Core will leverage existing, institutionally-supported equipment and infrastructure to offer a full range of small animal and human functional, molecular, and anatomical imaging resources, including magnetic resonance imaging (MRI), computed tomography (CT), digital X-ray, optical, single photon emission computed tomography (SPECT), and positron emission tomography (PET). A unique feature of this core, VICC GI SPORE investigators will also have access to novel probe development resources that leverage the capabilities of the Vanderbilt Center for Molecular Probes (CMP), including high-throughput, diversity-oriented synthesis capabilities suitable for developing novel imaging compounds, as well as world-class preclinical and cGMP resources of the CMP radiochemistry facility. The MHMI has three Specific Aims: Aim 1. To develop, optimize, and provide quantitative surrogate molecular imaging biomarkers of colorectal cancer (CRC) for support of preclinical and clinical research; Aim 2. To provide support for imaging data analysis customized to project-specific applications, including co-registration and integration of multiple imaging modalities, along with quality control metrics to be performed as part of all preclinical and clinical research studies; Aim 3. To work with both the Tissue Pathology and Cellular Analysis (TPCA) Core and the Biostatistics and Bioinformatics (BBC) Core to establish strategies for networking of requests, specimen tracking, extraction of de-identified data relating to imaging, biospecimens, and other research data. Translational goal: Molecular imaging holds great promise to illuminate the cellular and molecular underpinnings of individual tumors. Complementary to genomic approaches, molecular imaging provides a quantitative, functional measure of tumor `phenotype', and, when coupled with other tissue-based or newer `liquid' biopsy approaches, can provide a wealth of biological information about individual tumors. The MHMI Core will provide VICC GI SPORE investigators a mechanism and the expert personnel required for advancing cutting-edge translational research in CRC through the use of non-invasive molecular imaging in mice and humans.

项目总结/摘要：小鼠和人类分子成像核心 小鼠和人类分子成像（MHMI）核心将在转化研究中发挥核心作用 范德比尔特-英格拉姆癌症中心（VICC）的使命SPORE在胃肠道（GI）癌症，提供 三个项目的最先进的成像资源，未来的试点和可行性研究，以及发展 research. MHMI核心将利用现有的机构支持的设备和基础设施， 全方位的小动物和人类功能，分子和解剖成像资源，包括 磁共振成像（MRI）、计算机断层扫描（CT）、数字X射线、光学、单光子发射 计算机断层扫描（SPECT）和正电子发射断层扫描（PET）。该核心的一个独特功能是VICC GI SPORE研究人员还将获得新的探针开发资源， 范德比尔特分子探针中心（CMP）的能力，包括高通量、面向多样性 适合开发新型成像化合物的合成能力，以及世界一流的临床前和 CMP放射化学设施的cGMP资源。MHMI有三个具体目标：目标1。为了发展， 优化并提供结肠直肠癌（CRC）的定量替代分子成像生物标志物， 支持临床前和临床研究;目标2。为定制的成像数据分析提供支持， 项目特定应用，包括多种成像模式的配准和集成，沿着 作为所有临床前和临床研究的一部分进行的质量控制指标;目标3。工作 组织病理学和细胞分析（TPCA）核心以及生物统计学和生物信息学 (BBC)核心是建立请求联网、样本跟踪、提取去身份信息的战略 与成像、生物标本和其他研究数据相关的数据。翻译目标：分子成像 很有希望阐明个体肿瘤的细胞和分子基础。互补 基因组方法，分子成像提供了肿瘤“表型”的定量功能测量，并且， 当与其他基于组织的或更新的“液体”活检方法结合时， 关于个别肿瘤的信息。MHMI核心将为VICC GI SPORE调查人员提供一种机制， 和专家人员所需的推进尖端的转化研究在CRC通过使用 非侵入性分子成像在小鼠和人类。