Core 2: Mouse and Human Molecular Imaging
核心 2:小鼠和人类分子成像
基本信息
- 批准号:10700844
- 负责人:
- 金额:$ 24.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-09 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AnimalsBioinformaticsBiologicalBiometryCancer CenterClinical ResearchColorectal CancerCoupledCyclic GMPDataData AnalysesDevelopmentDigital X-RayEquipmentFeasibility StudiesFunctional ImagingFutureGenomic approachHumanHuman ResourcesImageIndividualInfrastructureInstitutionMagnetic Resonance ImagingMalignant neoplasm of gastrointestinal tractMeasuresMissionMolecularMolecular ProbesMusOpticsPathologyPhenotypePilot ProjectsPlayPositron-Emission TomographyQuality ControlRadiochemistryReproduction sporesResearchResearch PersonnelResource DevelopmentResourcesRoleSpecimenTissuesTranslational ResearchWorkX-Ray Computed Tomographyanatomic imagingdata de-identificationgastrointestinalhuman imagingimaging biomarkerimaging facilitiesimaging modalityliquid biopsymolecular imagingnovelpre-clinicalpre-clinical researchresearch studysingle photon emission computed tomographytranslational goaltumor
项目摘要
PROJECT SUMMARY/ABSTRACT: Mouse and Human Molecular Imaging Core
The Mouse and Human Molecular Imaging (MHMI) Core will play a central role in the translational research
mission of the Vanderbilt-Ingram Cancer Center (VICC) SPORE in Gastrointestinal (GI) Cancer, providing
state-of-the-art imaging resources for three projects, future pilot and feasibility studies, and developmental
research. The MHMI Core will leverage existing, institutionally-supported equipment and infrastructure to offer
a full range of small animal and human functional, molecular, and anatomical imaging resources, including
magnetic resonance imaging (MRI), computed tomography (CT), digital X-ray, optical, single photon emission
computed tomography (SPECT), and positron emission tomography (PET). A unique feature of this core, VICC
GI SPORE investigators will also have access to novel probe development resources that leverage the
capabilities of the Vanderbilt Center for Molecular Probes (CMP), including high-throughput, diversity-oriented
synthesis capabilities suitable for developing novel imaging compounds, as well as world-class preclinical and
cGMP resources of the CMP radiochemistry facility. The MHMI has three Specific Aims: Aim 1. To develop,
optimize, and provide quantitative surrogate molecular imaging biomarkers of colorectal cancer (CRC) for
support of preclinical and clinical research; Aim 2. To provide support for imaging data analysis customized to
project-specific applications, including co-registration and integration of multiple imaging modalities, along with
quality control metrics to be performed as part of all preclinical and clinical research studies; Aim 3. To work
with both the Tissue Pathology and Cellular Analysis (TPCA) Core and the Biostatistics and Bioinformatics
(BBC) Core to establish strategies for networking of requests, specimen tracking, extraction of de-identified
data relating to imaging, biospecimens, and other research data. Translational goal: Molecular imaging holds
great promise to illuminate the cellular and molecular underpinnings of individual tumors. Complementary to
genomic approaches, molecular imaging provides a quantitative, functional measure of tumor `phenotype', and,
when coupled with other tissue-based or newer `liquid' biopsy approaches, can provide a wealth of biological
information about individual tumors. The MHMI Core will provide VICC GI SPORE investigators a mechanism
and the expert personnel required for advancing cutting-edge translational research in CRC through the use of
non-invasive molecular imaging in mice and humans.
项目总结/摘要:小鼠和人类分子成像核心
小鼠和人类分子成像(MHMI)核心将在转化研究中发挥核心作用
范德比尔特-英格拉姆癌症中心(VICC)的使命SPORE在胃肠道(GI)癌症,提供
三个项目的最先进的成像资源,未来的试点和可行性研究,以及发展
research. MHMI核心将利用现有的机构支持的设备和基础设施,
全方位的小动物和人类功能,分子和解剖成像资源,包括
磁共振成像(MRI)、计算机断层扫描(CT)、数字X射线、光学、单光子发射
计算机断层扫描(SPECT)和正电子发射断层扫描(PET)。该核心的一个独特功能是VICC
GI SPORE研究人员还将获得新的探针开发资源,
范德比尔特分子探针中心(CMP)的能力,包括高通量、面向多样性
适合开发新型成像化合物的合成能力,以及世界一流的临床前和
CMP放射化学设施的cGMP资源。MHMI有三个具体目标:目标1。为了发展,
优化并提供结肠直肠癌(CRC)的定量替代分子成像生物标志物,
支持临床前和临床研究;目标2。为定制的成像数据分析提供支持,
项目特定应用,包括多种成像模式的配准和集成,沿着
作为所有临床前和临床研究的一部分进行的质量控制指标;目标3。工作
组织病理学和细胞分析(TPCA)核心以及生物统计学和生物信息学
(BBC)核心是建立请求联网、样本跟踪、提取去身份信息的战略
与成像、生物标本和其他研究数据相关的数据。翻译目标:分子成像
很有希望阐明个体肿瘤的细胞和分子基础。互补
基因组方法,分子成像提供了肿瘤“表型”的定量功能测量,并且,
当与其他基于组织的或更新的“液体”活检方法结合时,
关于个别肿瘤的信息。MHMI核心将为VICC GI SPORE调查人员提供一种机制,
和专家人员所需的推进尖端的转化研究在CRC通过使用
非侵入性分子成像在小鼠和人类。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Henry Charles Manning其他文献
Henry Charles Manning的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Henry Charles Manning', 18)}}的其他基金
Quantitative Imaging of OXPHOS in Pancreatic Cancer
胰腺癌中 OXPHOS 的定量成像
- 批准号:
10649885 - 财政年份:2023
- 资助金额:
$ 24.23万 - 项目类别:
Quantitative PET Imaging of Hepatocellular Carcinoma (HCC)
肝细胞癌 (HCC) 的定量 PET 成像
- 批准号:
9890526 - 财政年份:2020
- 资助金额:
$ 24.23万 - 项目类别:
Quantitative PET Imaging of Hepatocellular Carcinoma (HCC)
肝细胞癌 (HCC) 的定量 PET 成像
- 批准号:
10687038 - 财政年份:2020
- 资助金额:
$ 24.23万 - 项目类别:
Quantitative PET Imaging of Hepatocellular Carcinoma (HCC)
肝细胞癌 (HCC) 的定量 PET 成像
- 批准号:
10267667 - 财政年份:2020
- 资助金额:
$ 24.23万 - 项目类别:
相似海外基金
Collaborative Research: IIBR: Innovation: Bioinformatics: Linking Chemical and Biological Space: Deep Learning and Experimentation for Property-Controlled Molecule Generation
合作研究:IIBR:创新:生物信息学:连接化学和生物空间:属性控制分子生成的深度学习和实验
- 批准号:
2318829 - 财政年份:2023
- 资助金额:
$ 24.23万 - 项目类别:
Continuing Grant
Analysis of biological small molecule mixtures using multiple modes of mass spectrometric fragmentation coupled with new bioinformatics workflows
使用多种质谱裂解模式结合新的生物信息学工作流程分析生物小分子混合物
- 批准号:
BB/X019802/1 - 财政年份:2023
- 资助金额:
$ 24.23万 - 项目类别:
Research Grant
Collaborative Research: IIBR: Innovation: Bioinformatics: Linking Chemical and Biological Space: Deep Learning and Experimentation for Property-Controlled Molecule Generation
合作研究:IIBR:创新:生物信息学:连接化学和生物空间:属性控制分子生成的深度学习和实验
- 批准号:
2318830 - 财政年份:2023
- 资助金额:
$ 24.23万 - 项目类别:
Continuing Grant
Collaborative Research: IIBR: Innovation: Bioinformatics: Linking Chemical and Biological Space: Deep Learning and Experimentation for Property-Controlled Molecule Generation
合作研究:IIBR:创新:生物信息学:连接化学和生物空间:属性控制分子生成的深度学习和实验
- 批准号:
2318831 - 财政年份:2023
- 资助金额:
$ 24.23万 - 项目类别:
Continuing Grant
Bioinformatics-powered genetic characterization of the impact of biological systems on Alzheimer's disease and neurodegeneration
基于生物信息学的生物系统对阿尔茨海默病和神经退行性疾病影响的遗传表征
- 批准号:
484699 - 财政年份:2022
- 资助金额:
$ 24.23万 - 项目类别:
Operating Grants
REU Site: Bioinformatics Research and Interdisciplinary Training Experience in Analysis and Interpretation of Information-Rich Biological Data Sets (REU-BRITE)
REU网站:信息丰富的生物数据集分析和解释的生物信息学研究和跨学科培训经验(REU-BRITE)
- 批准号:
1949968 - 财政年份:2020
- 资助金额:
$ 24.23万 - 项目类别:
Standard Grant
REU Site: Bioinformatics Research and Interdisciplinary Training Experience in Analysis and Interpretation of Information-Rich Biological Data Sets (REU-BRITE)
REU网站:信息丰富的生物数据集分析和解释的生物信息学研究和跨学科培训经验(REU-BRITE)
- 批准号:
1559829 - 财政年份:2016
- 资助金额:
$ 24.23万 - 项目类别:
Continuing Grant
Bioinformatics Tools to Design and Optimize Biological Sensor Systems
用于设计和优化生物传感器系统的生物信息学工具
- 批准号:
416848-2011 - 财政年份:2011
- 资助金额:
$ 24.23万 - 项目类别:
University Undergraduate Student Research Awards
ABI Development: bioKepler: A Comprehensive Bioinformatics Scientific Workflow Module for Distributed Analysis of Large-Scale Biological Data
ABI 开发:bioKepler:用于大规模生物数据分布式分析的综合生物信息学科学工作流程模块
- 批准号:
1062565 - 财政年份:2011
- 资助金额:
$ 24.23万 - 项目类别:
Continuing Grant
Bioinformatics-based hypothesis generation with biological validation for plant stress biology
基于生物信息学的假设生成和植物逆境生物学的生物验证
- 批准号:
261818-2006 - 财政年份:2010
- 资助金额:
$ 24.23万 - 项目类别:
Discovery Grants Program - Individual