BLRD Research Career Scientist Award Application

衰老是许多慢性疾病的最大风险因素，包括癌症、神经变性、糖尿病、 和心脏病目前，大约一半的退伍军人事务部人口年龄在65岁以上，在未来十年， 预计这些退伍军人中有300多万人将超过75岁。因此，研究调节衰老的基因 衰老相关的病理学对于生物医学的进步至关重要， 健康这项研究计划调查了两个这样的基因，SIRT6和SIRT7，它们是“主基因”。 衰老组织中许多变化的“调节因子”，如DNA损伤，代谢和氧化应激， 细胞衰老和炎症。我们的项目研究这些基因活性的降低如何可能 有助于心血管和肝脏疾病，糖尿病，肥胖和许多癌症的病理，以及如何 激活这些基因可以防止这些疾病。通过确定可以针对 对于治疗，这项研究可以直接影响退伍军人的健康。 .

Aging is the greatest risk factor for many chronic diseases including cancer, neurodegeneration, diabetes, and heart disease. Currently, roughly half of the VA population is aged 65+ years, and in the next ten years, more than 3 million of these veterans are expected to be over 75. Thus, studying genes that regulate aging and aging-associated pathologies is critically important for biomedical advancements to benefit veterans’ health. This research program investigates two such genes, SIRT6 and SIRT7, which are “master regulators” of many changes in aging tissues, such as DNA damage, metabolic and oxidative stress, cellular senescence, and inflammation. Our projects study how decreased activity of these genes may contribute to pathologies in cardiovascular and liver disease, diabetes, obesity, and many cancers, and how activating these genes could protect against these pathologies. By identifying pathways that can be targeted for therapy, this research can directly impact the health of the Veteran population. .