RCMI@Morgan: Center for Urban Health Disparities Research and Innovation

项目摘要 健康差距可归因于复杂的疾病，这些疾病涉及社会、环境和 遗传因素更好地了解疾病的机制和制定干预措施 需要最先进的研究设施，支持一流的，多学科的研究和参与 社区的一部分。研究基础设施核心（RIC）将提供行政结构， 仪器，以及进行多学科生物医学和健康差异研究所需的专业知识， 巴尔的摩的城市环境根据摩根州立大学当前和未来的研究需求， 将建立或加强核心研究机构（CRF）：1）动物研究中心（ARC）; 2.分子 和细胞生物学研究核心实验室（MCB）;和3.生物统计学和生物信息学支助股 （BBSU）。为了满足行为和基础科学研究人员的需求，ARC将由两个 单独的站点。它将由一名教师共同领导和一名核心经理管理。它将提供动物住房， 用于组织学/病理学、外科手术和行为学研究的测试室和先进仪器。一 来自约翰霍普金斯大学的一位兽医将担任ARC，负责监督研究的健康状况 动物MCB将由狄克逊研究中心的多个实验室组成，并将由 由一名联合主管和一名核心经理负责。它将为基因组学、流式细胞术、分子成像、 分子分析、纳米材料研究和其他尖端实验。BBSU将由 由一名教师共同领导，由一名教师生物信息学家协助。它将提供统计和生物信息学 为研究人员提供咨询和计算资源。BBSU将设在RCMI办公区， 波蒂奇三个病例报告表将开展外展活动、定期培训研讨会并促进传播 通过出版物和协助用户进行数据分析来传播研究结果。CRF将属于 大学作为共享设施，供任何MSU研究人员使用。监督委员会，由副 研究和经济发展总裁（DRED）和学校院长（工程， 科学，社会工作）和学院（社区卫生和政策和文科）的参与教师 将为PI和RIC负责人提供有关重大采购、空间分配、设施 人事变动。它将向校长和教务长提供有关生物医学研究需求的建议。 在区域协调管理倡议供资期之后，促进通用报告格式的可持续性。PI将讨论CRF的 定期与牵头人和共同牵头人进行业务合作，牵头人和共同牵头人将每月举行一次会议， 审查实现RIC目标的进展情况，解决任何问题，并制定战略 如何加强和维持不同领域的研究。资源，培训计划， 以及对教师和其他用户的推广工作将有助于巩固健康和健康领域的竞争性研究 摩根州立大学的差异。

Project Summary Health disparities are attributable to complex diseases that involve the interactions of social, environmental, and genetic factors. A better understanding of the mechanisms of the diseases and the development of interventions requires state-of-the-art research facilities that support top notch, multidisciplinary research and the involvement of the community. The Research Infrastructure Core (RIC) will provide the administrative structure, instrumentation, and expertise needed to perform multidisciplinary biomedical and health disparities research in the urban setting of Baltimore. Based on the current and future research needs at Morgan State University, three Core Research Facilities (CRFs) will be established or enhanced: 1) Animal Research Core (ARC); 2. Molecular and Cellular Biology Research Core Laboratory (MCB); and 3. Biostatistics and Bioinformatics Support Unit (BBSU). To meet the needs of both behavioral and basic science researchers, the ARC will consist of two separate sites. It will be managed by a faculty Co-Lead and a Core Manager. It will provide animal housing and testing rooms and advanced instrumentation for histology/pathology, surgery, and behavioral studies. A veterinary doctor from Johns Hopkins University will serve as the ARC's to oversee the health of research animals. The MCB will comprise of multiple laboratories in the Dixon Research Center and it will be managed by a Co-Lead and a Core Manager. It will provide support for genomics, flow cytometry, molecular imaging, molecular analyses, nanomaterials research, and other cutting-edge experiments. The BBSU will be managed by a faculty Co-Lead who will be assisted by a Faculty Bioinformatician. It will offer statistical and bioinformatics consultation and computational resources to researchers. The BBSU will be housed in an RCMI office area in Portage. The three CRFs will conduct outreach, regular training workshops, and will promote the dissemination of research findings through publications and by assisting users with data analyses. The CRFs will belong to the University as shared facilities for use by any MSU researcher. An Oversight Committee consisting of the Vice President for Research and Economic Development (DRED) and the deans of the schools (Engineering, Sciences, and Social Work) and colleges (Community Health and Policy and Liberal Arts) of participating faculty will provide guidance to the PI and RIC Lead on matters relating to major purchases, space allocations, facilities, and personnel changes. It will advise the president and provost on the biomedical research needs of the university and facilitate the sustainability of the CRFs beyond the RCMI funding period. The PI will discuss CRFs' operations with the Lead and Co-Leads regularly and the Lead and Co-Leads will meet monthly and as necessary to review progress towards meeting the objectives of the RIC, resolve any problems, and to strategize on how to enhance and sustain research in the different areas of interest. The resources, training programs, and outreach efforts to faculty and other users will serve to entrench competitive research in health and health disparities at Morgan State University.