Specific Pathogen Free Baboon Research Resource (SPFBRR) - Bridge Funding Administrative Supplement

项目总结 这项申请是为“无特定病原体的浣熊研究”申请过渡性资金 资源“(SPFBRR)P40 OD024628。SPFBRR是在加州大学国立卫生研究院的支持下成立的 俄克拉何马州健康科学中心(OUHSC)于2002年成立，并于2017年迁至基林中心。这个 SPFBRR自成立以来一直得到美国国立卫生研究院的支持。SPFBRR是唯一一个全国性的 NIH受资助者可获得的不定病毒脱毒橄榄狒狒(Papio Anubis)研究资源； 联邦机构的内部研究计划，包括FDA、NSF和NIH；以及 生物医学研究(私人基金会、制药公司和合同研究组织)。 在整个世界上绝对是独一无二的，SPFBRR中的狒狒有18种广泛的生物排斥名单 通常在其他野生和圈养的非人类灵长类动物群体中发现的病原体。SPFBRR已经 将多个学科整合到一个计划中，旨在满足利用其 资源。在拟议的支助期内，应急基金将继续改进其资源。 提供给用户，并将继续添加有关无病毒的生物学和研究价值的新信息 到它的网站上。狒狒仍是转基因猪的重要动物模型 异种移植是呼吸道合胞病毒和百日咳的唯一NHP模型，它们 仍然是细菌性败血症的一个非常重要的模型。此外，狒狒是人类的极好模型。 CoVID相关肺炎，他们在开发获得批准的疫苗方面发挥了重要作用 SARS CoV-2。在接下来的一年里，SPFBRR将专注于维持SPF18狒狒繁殖群体 以满足当前和未来的生物医学研究需求。SPFBRR的总体目标是提供一个 国家脱毒橄榄狒狒研究资源；提供狒狒来源的生物材料； 为科学家、蜂群管理人员和动物饲养员提供教育和培训机会 他们希望与狒狒合作；并为调查人员提供设施和专业知识来进行 使用无病毒的狒狒进行的研究。

PROJECT SUMMARY This application is a request for bridge funding for the “Specific Pathogen Free Baboon Research Resource” (SPFBRR) P40 OD024628. The SPFBRR was founded with NIH support at the University of Oklahoma Health Sciences Center (OUHSC) in 2002 and was relocated to the Keeling Center in 2017. The SPFBRR has received continuous NIH support since it was founded. The SPFBRR is the only national research resource of adventitious virus free olive baboons (Papio anubis) that are available to NIH grantees; intramural research programs of federal agencies, including the FDA, NSF and NIH; and other sponsors of biomedical research (private foundations, pharmaceutical companies, and contract research organizations). Absolutely unique in the entire world, the baboons in the SPFBRR have an extensive bioexclusion list of 18 pathogens normally found in other wild and captive nonhuman primate colonies. The SPFBRR has integrated multiple disciplines into a program designed to meet the needs of investigators who utilize its resources. During the proposed period of support, the SPFBRR will continue to improve the resources it provides to users and will continue to add new information about the biology and research value of virus free baboons to its website. Baboons continue to be important animal model for genetically engineered pig xenotransplantation, are the only NHP model of respiratory syncytial virus and whooping cough, and they remain a very important model of bacterial sepsis. Additionally, baboons are excellent models of human COVID associated pneumonia, and they were instrumental in the development of approved vaccines for SARS CoV-2. Over the next year the SPFBRR will focus on maintaining the SPF18 baboon breeding colony to meet current and future biomedical research needs. The overall goal of the SPFBRR is to provide a national research resource of virus free olive baboons; provide baboon derived biological materials; provide education and training opportunities to scientist, colony managers, and animal caregivers who want to work with baboons; and to provide investigators with facilities and expertise to conduct studies using virus free baboons.