State University of New York (SUNY) NEXT Clinical Site

纽约州立大学（SUNY）响应NINDS RFA的申请，作为神经科学临床试验卓越网络（NEXT）的临床站点参与。我们汇集了4个纽约州立大学学术健康中心（AHCs），他们当地的，多样化的社区，以及他们与医院（包括4个儿童医院）和诊所网络，大型转诊基地和患者数量以及行业的联系。这将确保一个强大的和可访问的基础设施，以促进快速发展和实施协议，成人和儿童被招募到整个纽约州的神经学临床试验。通过将4个纽约州立大学校区整合到一个应用程序中，我们创建了一个高度创新和相当大的患者网络，这些患者具有极其多样化的民族和种族背景，并结合了广泛而深入的教师（超过100名）疾病亚专业和专业知识。大约42%的州人口居住在这个SUNY NEXT应用程序所服务的县/区。因此，纽约州立大学NEXT能够在更快的时间内转变绩效模式，改善公共卫生，因为转诊和集水区的规模以及所见不同患者的普遍性。在过去的8年里，纽约州立大学跨校园项目的成功势头急剧增加，主要领导通过机构的硬资金和赠款形成并支持纽约州立大学学术健康卓越研究（REACH）的形成。这项SUNY NEXT提案将进一步加强基础设施并扩展我们的多校区临床试验网络，该网络目前包括U10 SUNY NEXT， U10 NETT Hub， U10 StrokeNET站点，U24 SIREN SubHub以及现在的CTSA。我们的经验包括在过去8年多的100多个神经病学试验。我们已经建立了这个网络，并继续完善它，以提供全面的疾病特异性专业知识（成人和儿科神经病学专家/亚专家），临床试验专业知识和经验，包括试验协调员，临床/转化研究基础设施，机构承诺，以及正在进行/扩大的社区投入和研究。我们的网络可以协调一个庞大的、地理位置不同的疾病研究者队伍，有效地实施研究，以应对特定疾病的机会（mta和cIRB已经使用），由SUNY NEXT提供支持，目前在NEXT网站的前1/3（25个站点中的第8个）进行招聘和保留，具有出色的数据质量。我们还有一组早期调查员（ESIs），包括代表性不足的少数族裔调查员，我们将在试验中对他们进行培训和指导（包括纽约州立大学范围内的视频亚专业远程教学），他们将竞争每年一次的职位，以提供资助的薪水支持。鉴于我们在远程医疗方面的专业知识和连接性，我们将探索在纽约州立大学附属的更偏远、更小的地点进行试验的可行性，以获得更多的农村美国人参与试验。我们的成功将改变协作构建试验的模式，并最终改善公共卫生。

This application from the State University of New York (SUNY) responds to the NINDS RFA to participate as a Clinical Site in the Network for Excellence in Neuroscience Clinical Trials (NEXT). We have brought together the 4 SUNY Academic Health Centers (AHCs), their local, diverse communities, and their liaisons with hospital (including 4 children's hospitals) and clinic networks, large referral bases and patient volumes, and industry. This will insure a robust and accessible infrastructure to facilitate rapid developmental and implementation of protocols for adults and children to be recruited into neurological clinical trials throughout NY state. By combing 4 SUNY campuses into one application, we have created a highly innovative and considerable network of patients with extremely diverse ethnic and racial backgrounds combined with vast breadth and depth of faculty (over 100) disease subspecialization and expertise. Approximately 42% of the state's population lives within the counties/boroughs serves by this SUNY NEXT application. The SUNY NEXT is therefore in a position to shift performance models and improve public health on a faster timeline because of the size of the referral and catchment area and generalizability of the diverse patients seen. Momentum for highly successful SUNY cross-campus projects has increased dramatically in the past 8 years with key leadership forming and supporting the formation of SUNY Research Excellence in Academic Health (REACH) via institutional hard dollars and grants. This SUNY NEXT proposal will further enhance infrastructure and expand our multi-campus Clinical Trials Network that currently includes a U10 SUNY NEXT, U10 NETT Hub, U10 StrokeNET sites, U24 SIREN SubHub, and now a CTSA. Our experience includes over neurology 100 trials in the past 8+ years. We have built this network and continue to refine it to provide a comprehensive array of disease-specific expertise (adults and pediatric neurologic specialists/subspecialists), clinical trial expertise and experience including trial coordinators, clinical/ translational research infrastructure, institutional commitment, and ongoing/expanding community-based input and research. Our network can coordinate a large, geographically diverse cadre of disease-based investigators to implement studies efficiently in response to disease-specific opportunities (MTAs and cIRB use already in place), supported by SUNY NEXT currently in the top 1/3 (8th of 25) of NEXT sites for recruitment and retention with outstanding data quality. We also have a group of early stage investigators (ESIs), including under-represented minority investigators, who we will train and mentor in trials (including SUNY-wide video subspecialty telementoring) and who will compete for a yearly slot that protects time with funded salary support. We will explore, given our expertise and connectivity in telemedicine, the feasibility of performing trials to more remote, smaller sites affiliated with SUNY NEXT to gain even greater representation of rural Americans into trials. Our success will shift paradigms for collaborative structuring of trials and ultimately improve public health.