Center for Translational Pediatric Research (CTPR): Enhancing SARS-CoV-2 Sequencing Efforts for Variants in the State of Arkansas

摘要 2017年7月，我们在阿肯色州启动了科布雷转化性儿科研究中心第一阶段 阿肯色州小石城的儿童研究所。该中心的任务是利用蛋白质基因组学 确定影响包括癌症在内的疾病的表观基因组机制和治疗靶点的方法 或对儿科人群可翻译的。中心成员研究的统一主题是利用 研究疾病机制的系统生物学方法和尖端生物信息学。的目标是 第一阶段是建立中心的基础，扩大成功的调查员队伍 制定发展规划，支持系统级核心资源。为了实现这一目标，该中心是用一个 4个研究项目负责人和2个研究核心的核心，蛋白质组学核心和基因组和生物信息学 核心。通过使用由行政核心监督的指导教师发展计划，初级教师 第一阶段的研究人员获得了9项RPG级别的资助，其中包括一项U01奖。此外，我们还能够 “毕业”两个阶段的研究都是以自我维持为核心的。总体而言，在过去四年的第一阶段，我们 在建立一个多学科的专题研究中心方面取得了实质性进展，通过 我们中心成员的扩大，核心资源向独立的过渡，以及外部资金- 展示了该中心如何在科布雷支持之外朝着长期可持续发展的方向前进。 在第一阶段的基础上，我们在第二阶段的目标是进一步加强我们的院校研究 基础设施，通过战略扩张发展我们的多学科、主题研究中心 大量调查人员，投资于研究基础设施，并实施长期中心计划 超越科布雷支持的可持续性。我们将为最初的5人小组提供有组织的指导和支持 第二阶段的研究项目负责人。此外，我们将通过以下方式扩大中心的调查员队伍 机构承诺招聘4名助理和1名副教授或正教授到中心。支持需求 在不断扩大的研究人员临界量中，我们将开发一种新的蛋白质组学核心，这对于 该中心不断发展的研究任务。这一独特的核心将为研究项目负责人和其他人员提供 中心成员可以接触到经验丰富的人员，了解非标准蛋白质组、基因组和表观基因组 应用程序，以及获得高技能的生物信息学家，以进行尖端数据分析和集成。至 支持扩大调查人员和新的研究核心，行政核心将提供一个院系 发展计划、试点项目计划、运营监督和中心准备的领导力 向长期可持续性过渡。在第二阶段完成后，我们预计将有一个临界数量的初级， 职业生涯中期，以及该中心的高级研究员，他们可以接触到世界级的系统生物学核心，其中 将使中心成员能够成功地竞争个人、多名调查员和项目级别的拨款 支持中心向超越科布雷支持的长期可持续性过渡。

Summary In July of 2017, we launched Phase I of the COBRE Center for Translational Pediatric Research at Arkansas Children’s Research Institute in Little Rock, Arkansas. The mission of the center is to use proteogenomic approaches to identify epigenomic mechanisms and therapeutic targets in diseases, including cancer, impacting or translatable to the pediatric population. The unifying theme of research among center members is utilizing systems biology approaches and sophisticated bioinformatics for studying disease mechanism. The goal of Phase I was to establish the foundation of the center, expand the pool of successful investigators with a Faculty Development Plan, and support systems-level core resources. Towards this goal, the center was created with a nucleus of 4 Research Project Leaders and 2 research cores, Proteomics Core and Genomics & Bioinformatics Core. Through use of a mentored Faculty Development Program overseen by the Administrative Core, the junior investigators from Phase I received 9 RPG-level grants, including an U01-award. Additionally, we were able to “graduate” both Phase I research cores to self-sustainability. Collectively, during the past 4 years of Phase I, we have made substantial progress towards establishing a multi-disciplinary, thematic research center through expansion of our center members, transitioning core resources to independence, and extramural funding – demonstrating how the center is moving in the direction of long-term sustainability beyond COBRE support. Building on the momentum of Phase I, our goals in Phase II are to further enhance our institutional research infrastructure by developing our multi-disciplinary, thematic research center through strategic expansion of the critical mass of investigators, investing into research infrastructure, and implementing a plan for long-term center sustainability beyond COBRE support. We will provide structured mentoring and support to an initial group of 5 Research Project Leaders in Phase II. Furthermore, we will expand the pool of investigators in the center through institutional commitments to recruit 4 Assistant and 1 Associate or Full Professor to the center. To support needs of the expanding critical mass of investigators, we will develop a new Proteogenomics Core that is essential for the evolving research mission of the center. This unique core will provide Research Project Leaders and other center members access to experienced personnel for non-standard proteomic, genomic, and epigenomic applications, and access to highly skilled bioinformaticians for cutting-edge data analysis and integration. To support the expansion of investigators and a new research core, the Administrative Core will provide a Faculty Development Plan, Pilot Project Program, operational oversight, and leadership as the center prepares to transition to long-term sustainability. Upon completion of Phase II, we anticipate having a critical mass of junior, mid-career, and senior investigators in the center who have access to world-class systems biology cores, which will enable center members to successfully compete for individual, multi-investigator, and program-level grants to support transition of the center to long-term sustainability beyond COBRE support.