Studies to Advance Recovery Supports (STARS) in Central Appalachia

项目摘要 阿片类药物使用障碍和过量死亡代表着一种国家公共卫生危机，尤其是 在阿巴拉契亚中部急性发作了几十年。虽然治疗的可获得性和参与度在 在阿巴拉契亚，恢复支持生态系统的质量反映在一小部分人身上 世卫组织成功地维持了阿片类药物使用障碍(MOUD)的治疗或在康复期间放弃治疗。 作为社区和治疗的交汇点，同伴康复支持服务(PRSS)的价值尤其高 加强治疗结果和康复进程的建议，尽管目前有 提供其实践和使用内容的证据有限，特别是在穆德的情况下。而当 阿巴拉契亚中部迫切需要推进恢复支持服务的研究， 基本基础设施，如研究能力、参与的临床研究地点和数据基础设施仍保留 实施和研究PRSS的障碍。作为回应，提前恢复支持研究(STAR) 网络是一个以利益攸关方为重点的专题研究网络，将从一个既定的区域启动 研究联盟-阿巴拉契亚中部阿片研究联盟(ORCCA)。以下是 网络目标将通过利用ORCCA固有的资产并专注于PRSS来执行 在穆德诊所接受治疗的个人：1)建立大学和卫生系统合作伙伴的能力，以 开展社区参与的PRSS研究；2)招募Moud诊所和PRSS专业人员 促进承诺参与快速开展减贫战略研究；3)推动进程和技术，以 统一数据和研究效率，推动各机构合作伙伴开展减贫战略研究；以及4) 先进的STARS网络能力，使用严谨的设计进行快速周期干预研究。一个 动态团队，由ETSU和弗吉尼亚理工大学的研究人员联合领导，由ORCCA协助 在恢复方面有丰富经验的机构和PRSS合作伙伴为成功执行提供了保证。这个 拟议的工作具有创新性，因为它将一个老牌阿片研究财团的资产调整为 最高效率，展示了恢复就绪型生态系统模型的新应用，并创建了 严格开发PRSS专业人员和Moud诊所的评估工具和关键队列平台 用于恢复研究的目的。拟议的工作意义重大，因为预期结果和 产品将缓解当前阻碍高优先级PRSS研究的障碍，并为其奠定基础 阿巴拉契亚中部地区(肯塔基州、田纳西州、弗吉尼亚州、西弗吉尼亚州)，这是一个被阿片类药物危机摧毁的地区。与 NIDA使命，我们这项工作的长期目标是通知恢复支持服务的扩展， 特别是PRSS，并促进接受Moud治疗的个人的康复。

PROJECT ABSTRACT Opioid use disorder and overdose deaths represent a national public health crisis that has been particularly acute in central Appalachia for decades. While treatment access and engagement are improving across Appalachia, the quality of the recovery support ecosystem is reflected in the small percentage of individuals who successfully maintain treatment with medications for opioid use disorder (MOUD) or abstain in recovery. An interface of community and treatment, peer recovery support services (PRSS) are a particularly high value proposition to enhance treatment outcomes and the recovery process, though one for which there is currently limited evidence to inform the content of their practice and use, particularly in the context of MOUD. While research to advance recovery support services is urgently needed in central Appalachia, insufficiencies in basic infrastructure, such as research capacity, engaged clinical research sites, and data infrastructure remain barriers to PRSS implementation and study. In response, the Studies To Advance Recovery Support (STARS) Network, a thematic, stakeholder-focused research network, will be initiated from an established regional research consortium—the Opioids Research Consortium of Central Appalachia (ORCCA). The following network aims will be executed by leveraging assets inherent to ORCCA and concentrating on PRSS for individuals treated in the context MOUD clinics: 1) build university and health system partner capacity to conduct community-engaged PRSS research; 2) enroll cohorts of MOUD clinics and PRSS professionals to foster commitment to engage in rapid conduct of PRSS studies; 3) advance processes and technologies to harmonize data and research efficiencies that advance PRSS studies across institutional partners; and 4) advance STARS network capacity to conduct rapid-cycle intervention research using rigorous designs. A dynamic team, jointly led by established ETSU and Virginia Tech researchers and facilitated by ORCCA institutions and PRSS partners with lived experience in recovery, offer assurance of successful execution. The proposed work is innovative because it aligns assets of an established opioids research consortium for maximum efficiency, demonstrates a novel application of the Recovery Ready Ecosystem Model, and creates rigorously developed assessment tools and critical cohort platforms of PRSS professionals and MOUD clinics for the purpose of recovery research. The proposed work is significant because the expected outcomes and products will mitigate current barriers to, and establish a foundation for, high-priority PRSS research in the central Appalachian region (KY, TN, VA, WV), a region devastated by the opioid crisis. Consistent with the NIDA mission, our long-term goal for this work is to inform the expansion of recovery support services, particularly PRSS, and advance recovery among individuals treated with MOUD.