The Einstein-Montefiore Diversity, Equity, Inclusion, and Accessibility (DEIA) Mentorship program

摘要 这是对R 01的补充建议，标题为了解细胞和转录调控 人类衰老的变化。它响应了NOT-OD-22-057，特别关注通知（NOSI）：行政 补充，以表彰卓越的多样性，公平，包容性和可访问性（DEIA）导师。 父母R 01研究与人类衰老有关的“表观遗传”事件，超出了典型的 将细胞重编程事件考虑为系统性细胞亚型比例变化， 随着年龄的增长，功能性DNA序列变异的暴露。 由于该项目允许开发技术，允许深入了解非基因组中的DNA序列变异， 编码区，可以影响疾病的风险，在不同的遗传祖先的人，代表强烈 我们在布朗克斯的社区，该项目吸引了来自不同的，代表性不足的个人， 一名土著博士后和一名西班牙裔毕业生获得了多样性补助金 学生. 虽然这种资金个别来说是非常宝贵的，但很明显，需要有一个更普遍的 建立体制环境，促进那些来自通常被排斥群体的人的职业发展。NOSI描述了 上述提供了机会，以资助一个机构范围内的计划，以提高这些下的职业生涯- 代表同事。 我们描述了一个密集的一年计划，以制定和实施新的课程，实现这一目标。我们将 利用现有的机构资源，开发新的项目，并利用外部咨询资源， 新的综合路线。 我们将保护计划参与者和教师的时间，并将系统地收集有关 计划，使我们将在今年年底，收集足够的数据，以指导如何进行资源 投资要有针对性。 我们的目标是引导我们机构发展一个公平的环境，提供非常积极的培训 对于那些来自少数群体的人，培养未来的领导者，他们将扩大培训的好处， 我们学术界越来越多的人。

ABSTRACT This is a proposal for a supplement to the R01 entitled Understanding cellular and transcriptional regulatory changes in human aging. It responds to NOT-OD-22-057, the Notice of Special Interest (NOSI): Administrative Supplements to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) Mentorship. The parent R01 studies the ‘epigenetic’ events involved with ageing in humans, extending beyond the typical consideration of cellular reprogramming events into systematic cell subtype proportional changes, and the unmasking of functional DNA sequence variants with age. As this project permits the development of techniques that permit insights into DNA sequence variants in non- coding regions that can influence the risk of disease in people of diverse genetic ancestry, represented strongly by our community here in the Bronx, the project has attracted individuals from diverse, under-represented groups, with diversity supplements awarded to an indigenous postdoctoral fellow and a Hispanic graduate student. While such funding is individually very valuable, it has become apparent that there needs to be a more general institutional climate in place to foster the careers of those from typically excluded groups. The NOSI described above provides the opportunity to fund an institution-wide program to enhance the careers of these under- represented colleagues. We describe an intensive one-year plan to develop and implement a new curriculum towards this goal. We will leverage existing institutional resources, develop new programs, and harness external consulting resources in a new, integrated course. We will protect the time of program participants and faculty, and will collect information systematically about the program so that we will, at the end of the year, have collected enough data to direct how ongoing resource investment should be targeted. Our goal is to guide our institution’s development of an equitable environment that provides very active training for those from minoritized groups, developing the future leaders who will amplify the benefits of the training to an increasingly large part of our academic community.