Center for Appalachian Research in Environmental Sciences-Integrated Health Sciences Facility Core (IHSFC)

项目摘要-综合健康科学设施核心 肯塔基大学阿巴拉契亚环境科学研究中心(UK-CARE) 综合健康科学设施核心(IHSFC)将促进环境健康方面的转化研究 科学(EHS)，从基础、临床、暴露评估和传播研究，到支持 并保持协作、多学科联系以及学术与社区的伙伴关系。一个关键要素 IHSFC的四个EHS翻译研究中心的形成：1-分子毒理学；2-临床 研究和数据科学；3-社区暴露评估；4-环境健康 沟通。每个中心将提供内容专业知识、支持和访问EHS方法和 服务，并促进翻译研究领域的项目开发。枢纽结构将 加强IHSFC内部学科多样性，支持全校整合和跨中心 沟通。IHSFC将在我们早期成功记录的基础上，完善我们的运营模式，并 瞄准中心成员之间的新伙伴关系，同时提供专家咨询、翻译研究 中心重新调整的科学主题的支持和团队建设战略：(A)对健康的影响 水中污染物(水)；(B)室内和室外空气污染物(空气)对健康的影响； 和(C)新出现的环境健康威胁(新威胁)。具体来说，IHSFC的目标是1) 提供EHS研究服务，2)提供EHS项目支持，3)增强翻译 研究伙伴关系。首先，IHSFC研究支持门户将调查员请求流定向到 IHSFC工作人员和相关中心领导，他们将中心成员链接到适当的核心(例如，分析 环境科学的化学核心和社区参与核心)和资源(例如，数据 管理和统计分析)，为项目提供便利。门户网站将促进协调、确定优先顺序、 在中心范围内跟踪和使用设施核心服务。第二，IHSFC枢纽领导将提供最好的EHS 与职业发展计划合作举办实践讲习班和培训课程。第三，我们 将建立由中心领导和其他中心成员组成的快速反应团队，以促进 研究翻译和合作伙伴关系，支持对社区识别的EHS威胁和 新的曝光。IHSFC将满足对支持以下各项的集中式和可访问核心的需求 中心内的多方向EHS研究活动，遍及英国校园，与社区调查人员一起， 与其他EHS核心中心合作，为有影响力的EHS产品组合提供及时的咨询和支持 研究项目，同时培养高度协作的机构EHS文化。IHSFC将扩大规模 专业知识和服务，增强核心在英国-CARE日常运营中的核心作用，并提供 基础设施，以促进EHS从基本问题到测试的进展和扩展， 临床实践和公共卫生影响，提高公共卫生和临床实践的环境卫生水平。

PROJECT SUMMARY – Integrative Health Sciences Facility Core The University of Kentucky Center for Appalachian Research in Environmental Sciences (UK-CARES) Integrated Health Sciences Facility Core (IHSFC) will facilitate translational research in environmental health science (EHS), ranging from basic, clinical, exposure assessment, and communication research, to support and sustain collaborative, multidisciplinary connections, and academic-community partnerships. A key element of the IHSFC is the formation of four EHS translational research hubs: 1-Molecular Toxicology; 2-Clinical Research and Data Sciences; 3-Community Exposure Assessment; and 4-Environmental Health Communication. Each hub will provide content expertise, support, and access to EHS methodologies and services, and facilitate project development across the translational research spectrum. The hub structure will enhance disciplinary diversity within the IHSFC and support campus-wide integration and cross-Center communication. The IHSFC will build on our record of early success, refining our operational model and targeting new partnerships among Center members while providing expert consultation, translational research support, and team building strategies across the Center’s re-aligned science themes: (a) Health Impacts of Waterborne Contaminants (WATER); (b) Health Impacts of Indoor and Outdoor Airborne Contaminants (AIR); and (c) Emerging Environmental Health Threats (EMERGING THREATS). Specifically, the IHSFC aims to 1) provide access to EHS research services, 2) deliver EHS project support, and 3) enhance translational research partnerships. First, the IHSFC Research Support Portal will direct the flow of investigator requests to IHSFC staff and relevant hub leaders who will link Center members to the appropriate cores (e.g., Analytical Chemistry Core for Environmental Sciences and Community Engagement Core) and resources (e.g., data management and statistical analysis) for project facilitation. The Portal will facilitate coordination, prioritization, tracking, and use of facility core services, Center-wide. Second, IHSFC hub leaders will provide EHS best practices workshops and training sessions in collaboration with the Career Development Program. Third, we will establish Rapid Response Teams, comprised of the hub leaders and other Center members, to promote research translation and partnerships, enabling prompt responses to community identified EHS threats and new exposures. The IHSFC will fulfill the need for a centralized and accessible core that supports multidirectional EHS research activities within the Center, across UK campus, with community investigators, and with other EHS Core Centers, providing timely consultation and support for an impactful portfolio of EHS research projects, while fostering a highly collaborative institutional EHS culture. The IHSFC will expand expertise and services, enhancing the core’s central role in daily UK-CARES operations, and provide the infrastructure to facilitate the progression and expansion of EHS from fundamental questions into testing, clinical practice, and public health impact to improve public health and clinical practice in environmental health.