Metal Exposure and Early Cardiovascular Risk in Adult E-Cigarette Users

总结 非酒精性脂肪性肝病（NAFLD）的特征在于肝脏中脂肪的积累（脂肪变性）， 没有大量的酒精消费。它是美国慢性肝病的主要原因， 被认为在代谢紊乱中起关键作用。最近的证据表明， 包括金属和类金属在内的污染物可能在NAFLD和其他代谢性疾病的发展中起作用。 结果。然而，研究金属暴露和肝损伤之间的关系，在一般情况下， 人口稀少，大多数证据是跨部门的。在这个多元化的补充，我们将利用数据 来自两个现有队列：VapeScan队列（父R01）和动脉粥样硬化的多种族研究， 砷研究（R01ES 028758）旨在检查金属暴露与代谢特征和肝脏的相关性 年轻成人（VapeScan）和成人（梅萨）人群中的脂肪变性。我们假设金属暴露（例如， 砷、镉、锰），包括混合物，与1）较高水平的代谢标志物相关 （2）肝脂肪含量高。我们的具体目标是：（1）确定金属（单独和作为一个 混合物）与代谢因素在不同的年轻人从纽约市。我们将使用来自 Vape Scan队列检查金属与风险代谢结果测量的关联 在空腹血清样本（血脂、葡萄糖）和检查期间（收缩压和血糖）测量的NAFLD因素 舒张压和身体质量指数）。 (2)确定金属混合物与亚临床肝病指标的相关性。我们将使用 来自梅萨的6，618名参与者的数据，MESA是一项针对白色、黑人、西班牙裔和华裔美国成年人的队列研究 从美国6个城市招募来研究金属暴露与肝脂肪变性的关系， 计算机断层扫描（CT）作为梅萨检查的一部分。该项目将提供新的证据， 有毒金属和混合物对代谢结果的作用，包括肝脏疾病，这可能有助于靶向 这些条件的可改变的疾病因素。此外，通过提供先进的技能、培训和研究， 机会MPH学生（4+1计划），重点是环境和分子流行病学，这 该项目将提高我们在哥伦比亚大学的研究团队的多样性，并在该领域的道路 环境健康科学

SUMMARY Non-alcohol fatty liver disease (NAFLD) is characterized by an accumulation of fat (steatosis) in the liver in the absence of significant alcohol consumption. It represents a leading cause of chronic liver disease in the U.S. and is believed to play a key role in metabolic disorders. Recent evidence suggests that exposure to environmental pollutants including metals and metalloids may play a role in the development of NAFLD and other metabolic outcomes. However, studies examining the association between metal exposures and liver injury in a general population are scant and most evidence is cross-sectional. In this diversity supplement, we will leverage data from two existing cohorts: the VapeScan cohort (parent R01) and the Multi-Ethnic Study of Atherosclerosis and Arsenic study (R01ES028758) to examine associations of metal exposure with metabolic profiles and hepatic steatosis in young adults (VapeScan) and adult (MESA) populations. We hypothesize that metal exposures (e.g., arsenic, cadmium, manganese), including mixtures, are associated with 1) higher levels of metabolic markers and 2) higher hepatic fat. Our specific aims are: (1) Determine the association of metals (alone and as a mixture) with metabolic factors in diverse young adults from New York City. We will use data from the Vape Scan cohort to examine the associations of metals with measures of metabolic outcomes that are risk factors of NAFLD measured in fasting serum samples (lipids, glucose) and during the examination (systolic and diastolic blood pressure and body mass index) at the baseline visit and two follow-visits over a 1.5 year period. (2) Determine the association of metal mixtures with subclinical measures of liver disease. We will use data from 6,618 participants in the MESA, a cohort study of White, Black, Hispanic, and Chinese American adults recruited from 6 U.S. cities to examine the association of metal exposure with hepatic steatosis measured by computed tomography (CT) as part of the MESA examination. This project will provide novel evidence on the role of toxic metals and the mixtures on metabolic outcomes, including liver disease, which can contribute to target modifiable disease factors of these conditions. Moreover, by providing advanced skills, training and research opportunities to an MPH student (4+1 program) with focus in Environmental and Molecular Epidemiology, this project will enhance diversity in our research team at Columbia University and down the road in the field of environmental health sciences.