The Administrative Core

总结 哥伦比亚大学消化与疾病研究中心（CU-DLDRC）于2019年成立， 在过去的15年里，通过基础，转化和临床的蓬勃发展， research. CU-DLDRC反映了其成员的热情，合作，生产力和成功， 以及哥伦比亚大学对消化系统疾病研究的长期机构支持。CU-DLDRC 由49个富有成效的成员（30个正式成员和19个准成员）组成的互动小组， 在成人和儿童消化系统疾病研究和护理方面的卓越表现。自CU-DLDRC成立以来， 行政核心（AC）通过以下努力加强了合作研究文化：（i） 促进跨学科网络和团队科学，以及基础和临床之间的合作 研究人员;（ii）促进教育、培训、导师制和多样性、公平和包容（DEI）;（iii） 支持新的调查员。CU-DLDRC的中心研究主题是“上皮细胞及其相互作用， 消化稳态和疾病”包括两个相互关联的子主题，对消化系统有重大影响。 健康：“上皮稳态、代谢和再生”（副主题1）和“上皮相互作用 炎症和癌前病变”（副主题2）。四个生物医学核心为您提供 技术和设施：临床研究和生物标本;类器官和细胞培养;生物成像;以及 生物信息学和单细胞分析。CU-DLDRC包括主动试点和可行性（P/F）， 丰富（EP）计划，赋予下一代科学家权力，促进教育和 智力交流。作为CU-DLDRC的核心组成部分，AC将有助于整理和 通过研究基地的最佳组织实施其使命、活动和成功;财政 管理;其组成部分的协调、评价和持续发展;以及与 监督委员会、NIDDK和其他DDRCC。AC由经验丰富的领导者领导， 互补专业知识：Robert施瓦贝，医学博士、博士（主任）; Timothy Wang，医学博士和Kara Margolis，医学博士 （副董事），由AC管理员Seetha Srinivasan博士支持。AC将促进使命 CU-DLDRC通过这些具体目标取得的成功：通过有效的 行政管理、预算监督、科学领导以及与监督委员会的互动（目标1）。到 确保生物医学中心（Aim）提供最先进的服务、高效的运营和跨中心协作 2）。通过P/F计划（目标3）促进下一代科学家并监测他们的成功。促进 通过研讨会和务虚会提供丰富的环境和知识交流，并通过欧洲议会促进DEI (Aim 4）。在我们的网站上突出CU-DLDRC，其核心，教育活动和成就（Aim 5）。成功实现这些目标将有助于CU-DLDRC的有效性和成功。

SUMMARY The inception of the Columbia University Digestive and Disease Research Center (CU-DLDRC) in 2019 has its foundational roots over the past 15 years through the resounding growth of basic, translational and clinical research. The CU-DLDRC reflects the enthusiasm, collaborations, productivity and success of its members as well as the long-term institutional support of digestive disease research at Columbia University. The CU-DLDRC comprises an interactive group of 49 highly productive members (30 full and 19 associate), united by their strive for excellence in adult and pediatric digestive disease research and care. Since the CU-DLDRC’s inception, the Administrative Core (AC) has enhanced the collaborative research culture through the following endeavors: (i) Fostering interdisciplinary networks and team science, and collaborations between basic and clinical researchers; (ii) promoting education, training, mentorship and diversity, equity and inclusion (DEI); and (iii) supporting new investigators. The CU-DLDRC’ central research theme “Epithelial Cells and their Interactions in Digestive Homeostasis and Disease” encompasses two interrelated subthemes with major impact on digestive health: “Epithelial Homeostasis, Metabolism and Regeneration” (Subtheme 1) and “Epithelial Interactions in Inflammation and Preneoplasia” (Subtheme 2). Four Biomedical Cores provide access to cutting-edge technologies and facilities: Clinical Research and Biospecimen; Organoid and Cell Culture; Bioimaging; and Bioinformatics and Single Cell Analysis. The CU-DLDRC includes active Pilot and Feasibility (P/F) and Enrichment (EP) Programs, empowering the next generation of scientists and promoting education and intellectual exchange. The AC, as central component of the CU-DLDRC, will contribute to the collation and implementation of its mission, activities and success via optimal organization of the research base; fiscal management; coordination, evaluation and continuous evolution of its components; and communication with oversight committees, the NIDDK and other DDRCCs. The AC is directed by experienced leaders with complementary expertise: Robert Schwabe, MD, PhD (Director); Timothy Wang, MD and Kara Margolis, MD (Associate Directors), supported by AC administrator Seetha Srinivasan, PhD. The AC will promote the mission and success of the CU-DLDRC through these Specific Aims: To provide governance through efficient administration, budgetary oversight, scientific leadership and interactions with oversight committees (Aim 1). To ensure state-of-the-art services, efficient operation and cross-core collaboration by the Biomedical Cores (Aim 2). To promote the next generation of scientists and monitor their success via the P/F Program (Aim 3). To foster a fertile environment and intellectual exchange through seminars and retreats, and to promote DEI via the EP (Aim 4). To highlight the CU-DLDRC, its cores, educational activities and accomplishments on our website (Aim 5). Successful realization of these Aims will contribute to the effectiveness and success of the CU-DLDRC.