Novel 'Mechano-medicine' combats deadly sticky blood clots in diabetes

该项目旨在阐明一种新的生物力学机制，该机制与动态血流产生的机械力有关，并导致糖尿病患者凝血功能增强。这一结果可能解释了目前抗凝血药物(即阿司匹林、Plavix®或Brilinta®)对糖尿病患者疗效降低的原因，这一结果没有考虑到力量效应。此外，它还将提供一种创新的治疗策略，以减少糖尿病引起的粘性血栓。

This project aims to elucidate a novel biomechanical mechanism that associates with mechanical force generated by dynamic blood flow and leads to enhanced blood clotting in diabetes. The outcome may likely explain the reduced efficacy of current anti-clotting drugs (i.e. Aspirin, Plavix® or Brilinta®) in individuals with diabetes, which does not take the 'force effect' into account. Moreover, it will provide an innovative therapeutic strategy to reduce the sticky blood clots of diabetes.