Core - Pilot Program

项目总结： 表观遗传学酒精研究中心(CARE)P50申请试点项目核心目标 是作为一个平台，带来酒精研究的新研究方向，并吸引新的研究人员 酒精研究领域。护理的总体假设是慢性酒精暴露和戒断 改变表观基因组以产生差异基因表达模式，从而机械地改变大脑 在酒精使用障碍发病机制中的作用。我们已经包括了两个令人兴奋和相关的飞行员 AUD中的项目、表观遗传生物标记物以及表观转录组学在AUD中的作用。第二套试点项目 还将宣布，然后选择第三年和第五年的护理资金，以涵盖几个重要的 研究领域包括创伤后应激障碍(PTSD)和创伤后脑的表观遗传学基础 损伤(TBI)与AUD并存。研究清楚地表明，HDAC抑制剂能够减弱酒精。 在几种酒精中毒动物模型中的消费。伏立诺(SAHA)是FDA批准用于治疗 皮肤T细胞淋巴瘤，因此我们建议在澳大利亚进行SAHA的初步临床研究，作为 未来的试点项目。另一个将被探索的领域是澳大利亚的单细胞表观基因组学。行政部门 CARE的核心将对当前和未来的试点项目提供领导、全面管理和监督。 试点项目部分的具体目标是：1)管理运营、进度和完成 在CARE资助期间，对当前和未来的试点项目进行评估。2)宣布新的试点项目并进行管理 审查过程由项目咨询委员会成员负责。新的试点项目将 吸引新的研究人员和有趣的研究领域到酒精研究领域。这些试点项目将 此外，加强表观遗传主题的关怀，并允许这些调查人员申请国家卫生研究院的资金 建立机制，使其成为成熟的酒精研究人员，从而实现试点项目核心的目标。

Project Summary: The objective of pilot project core of the P50 application for “Center for Alcohol Research in Epigenetics (CARE)” is to serve as a platform to bring new research directions in alcohol research and attract new investigators to alcohol research field. The overall hypothesis of the CARE is that chronic alcohol exposure and withdrawal changes the epigenome to produce differential gene expression patterns that mechanistically alter brain function during the pathogenesis of alcohol use disorder. We have included two exciting and relevant pilot projects, epigenetic biomarkers in AUD and the epitranscriptome’s role in AUD. A second set of pilot projects will also be announced and then selected for the 3rd and 5th years of CARE funding to cover several important research areas which includes epigenetic basis of post-traumatic stress disorder (PTSD) and tramautic brain injury (TBI) comorbid with AUD. Studies clearly suggest that HDAC inhibitors are able to attenuate alcohol consumption in several animal models of alcoholism. Vorinostat (SAHA) is FDA-approved for the treatment of cutaneous T-cell lymphoma, therefore we propose to conduct an initial clinical study of SAHA in AUD as one of the future pilot projects. Another area that will be explored is single cell epigenomics in AUD. The administrative core of the CARE will provide leadership, overall management, and oversight of current and future pilot projects. The Specific Aims of the pilot project component are: 1) To manage the operation, progress, and completion of current and future pilot projects during CARE funding. 2) To announce new pilot projects and manage the review process by the members of Program Advisory Committee of the CARE. New pilot projects will attract new investigators and interesting research areas to the alcohol research field. These pilot projects will furthermore strengthen the epigenetic theme of CARE and allow these investigators to apply for NIH funding mechanisms to become full-fledged alcohol researchers, thus fulfilling the objectives of the Pilot Project Core.