LA-Aging Diversity Supplement

项目总结/摘要 总体-项目摘要 肥胖和2型糖尿病被描述为加速老化。有很多人试图穿越 数十年来开发和验证加速老化的可测量结构。我们进行了研究 在两次成功的NIDDK资助的多样性补充的支持下， 在Look AHEAD队列中，累积虚弱指数到前8年随访的时间跨度， 所有参与者都被分配到积极干预。这是一项富有成效的事业。我们有 公布： 展望未来强化生活方式干预（ILI）为FI的增加提供了缓冲， 与对照组中的一年老化成比例 在基线时FI相对较低的参与者中，ILI导致主要 然而，在基线时FI评分最高的参与者中，ILI 与心血管事件的发生率增加有关 展望未来ILI在全范围内保留认知功能方面同样无效。 基线FI 8年内FI的增加与随后的死亡风险增加有关， 身体和认知功能的轨迹较差 我们建议利用 展望未来队列，1）将最初由展望未来开发的赤字累积FI扩展到 第8年到展望未来扩展（18年）结束，产生FIE; 2）制定统计 将本FI与母基金（LA-老龄化）为19-23年随访开发的FI连接起来的桥梁 (FIA)3）研究FIE的轨迹如何与Look中老年综合征的患病率相关 AHEAD老化研究。如果成功，该项目将提供一个经过验证的长期生物老化标志物， 可以作为临床试验的结果指标，也可以作为识别老年人中延缓衰老的因素的工具。 2型糖尿病和肥胖的成年人。 这个项目的一个补充目标是进一步发展乔纳森罗斯，一个有前途的 温斯顿-塞勒姆州立大学的一名本科生，这是一所历史悠久的黑人公立研究型大学。他 主要导师将是Mark Espeland博士，他经验丰富，非常适合这一角色。我们回应PA- 21-071促进健康相关研究多样性的研究补充材料。计划汇总 对展望未来计划的贡献。本申请随附于1U 01 AG 073697 -01：健康行动 糖尿病（展望未来）扩展随访（LA-老化）Mark A。Espeland，博士，双校长 调查员

Project Summary/Abstract OVERALL – PROJECT SUMMARY Obesity and type 2 diabetes are described as accelerators aging. There have been numerous attempts across decades to develop and validate measureable constructs for accelerated aging. We have conducted research supported by two prior successful NIDDK-funded diversity supplements to develop and apply deficit accumulation frailty indices to the first 8 years of follow-up in the Look AHEAD cohort, the span of time when all participants were assigned to active interventions. This has been a productive enterprise. We have published that:  The Look AHEAD intensive lifestyle intervention (ILI) created a buffer against increases in FI, roughly proportional to one year of aging in the control group  Among participants with relatively low FI at baseline, the ILI resulted in lower incidence of major cardiovascular disease events, however among participants with the highest FI scores at baseline, the ILI was associated with an increased incidence of cardiovascular events  The Look AHEAD ILI was equally ineffectual in preserving cognitive function across the full range of baseline FI  Greater increases in FI across 8 years was associated with subsequent increased risk for mortality and poorer trajectories of physical and cognitive function We propose to conduct a series of secondary data analyses, using the extensive data resources provided by the Look AHEAD cohort, 1) to extend the deficit accumulation FI originally developed by Look AHEAD through year 8 to the close-out of the Look AHEAD Extension (Year 18), producing FIE; 2) to develop a statistical bridge linking this FI with one being developed by the parent grant (LA-Aging) for years 19-23 of follow-up (FIA); and 3) to examine how trajectories of FIE are related to the prevalence of geriatric syndromes in the Look AHEAD Aging study. If successful, this project will provide a validated marker of long-term biological aging that can serve as an outcome measure in clinical trials and a tool for identifying factors that slow aging among older adults with type 2 diabetes and obesity. A complementary goal of this project is to further the development of Johnathan Ross, a promising undergraduate student at Winston-Salem State University, a historically black public research university. His primary mentor will be Dr. Mark Espeland, who is experienced and well-suited for this role. We respond to PA- 21-071 Research Supplements to Promote Diversity in Health-Related Research. Summary of Planned Contributions to the Look AHEAD Program. This request is attached to 1U01AG073697-01: Action for Health in Diabetes (Look AHEAD) Extended Follow-up (LA-Aging) Mark A. Espeland, PhD, Dual Principal Investigator.