Cancer Center Support (Core) Grant

总体：摘要/摘要 在过去的40年里，麻省理工学院一直致力于癌症研究，首先是以麻省理工学院中心的形式 自2007年起，他被任命为麻省理工学院科赫综合癌症研究所。 这一努力一直得到国家癌症中心支持赠款(CCSG)的持续支持 癌症研究所(NCI)，提供指定为NCI指定的麻省理工学院癌症中心。通过提供 为科赫研究所的核心设施和其他组织部分以及 作为教师招聘和试点项目的资金，这一CCSG是麻省理工学院癌症研究的关键资源。 从1974年CCR成立到过渡到科赫研究所，一直延续到现在， NCI癌症中心的指定对麻省理工学院的管理产生了强大的影响，导致了显著的 整个时期的体制支持。科赫学院大楼的建设投资 (2010年底开业)是这种支持的最新迹象。这座大楼聚集了27名癌症科学家 和面向癌症的工程师，形成高度跨学科和协作的研究环境。这个 大楼也是麻省理工学院校园癌症研究的中心，几乎有相同数量的成员 中心的实验室设在附近的其他研究大楼。56名中心成员是从 麻省理工学院科学学院或工程学院的八个学术部门。除了这一发现 该中心成员正在进行的研究和技术开发，其重点是 以与临床中心和行业合作伙伴合作的形式，致力于转化性研究。 科赫研究所的研究分为三个项目。这些计划中的每一个都取得了重要的成就 在本授权期内的预付款。计划1：癌症中的遗传和细胞计划由Dr。 菲利普·夏普、J·克里斯托弗·洛夫和埃利泽·卡洛。计划2：癌症生物学与免疫学由 理查德·海因斯博士、戴恩·维特鲁普博士和斯蒂芬妮·斯布兰格博士。方案3：系统工程方法 致癌组织由迈克尔·亚菲博士、斯科特·马纳利斯博士和安吉拉·克勒共同领导。这些程序的功能是 激发其成员的新研究活动，并促进方案内和方案间的研究 合作。该中心的56名成员总共发表了1006篇与癌症有关的文章 过去的授权期。其中，近18%涉及多个成员。该中心有一个与癌症有关的 58,596,507美元的贸易发展中心供资基数(见数据表2A/2B)。

Overall: Summary/Abstract Over the past four decades, MIT has had a focused effort in cancer research, first in the form of the MIT Center for Cancer Research (CCR) and, since 2007, as the Koch Institute for Integrative Cancer Research at MIT. This effort has been continuously supported by a Cancer Center Support Grant (CCSG) from the National Cancer Institute (NCI), providing the designation as an NCI-designated Cancer Center at MIT. By supplying infrastructural support for Core Facilities and other organizational components of the Koch Institute as well as funds for faculty recruitment and pilot projects, this CCSG is a critical resource for cancer research at MIT. From the establishment of the CCR in 1974 to the transition to the Koch Institute and continuing to the present, the NCI Cancer Center designation has had a strong influence on the MIT administration, leading to significant institutional support over this entire period. The investment in construction of the Koch Institute building (opened in late 2010) is a recent indication of this support. The building brings together 27 cancer scientists and cancer-oriented engineers to form a highly inter-disciplinary and collaborative research environment. The building is also the hub of cancer research on the MIT campus, with a nearly equal number of Members of the Center having their laboratories in other research buildings nearby. The 56 Center Members are drawn from eight academic departments at the School of Science or School of Engineering at MIT. Beyond the discovery research and technology development being pursued by the Members of this Center, significant emphasis is placed on translational research in the form of collaborations with clinical centers and industry partners. Research in the Koch Institute is organized into three Programs. Each of these Programs has made significant advances over the current grant period. Program 1: Genetic & Cellular Programs in Cancer is co-led by Drs. Phillip Sharp, J Christopher Love, and Eliezer Calo. Program 2: Cancer Biology & Immunology is co-led by Drs. Richard Hynes, Dane Wittrup, and Stefani Spranger. Program 3: Systems and Engineering Approaches to Cancer is co-led by Drs. Michael Yaffe, Scott Manalis, and Angela Koehler. These Programs function to stimulate new research initiatives by their Members as well as to foster intra- and inter-programmatic collaborations. In aggregate the 56 Members of this Center have published 1006 cancer-related articles over the past grant period. Of those, nearly 18% have involved multiple Members. The Center has a cancer-related funding base of $58,596,507 TDC (see Data Tables 2A/2B).