Data Management and Statistical Core

数据管理和统计核心：摘要/摘要： 数据管理和统计核心 (DMSc)促进与当地阿尔茨海默病(AD)研究人员的研究和合作，国家 提供高质量的数据管理和方法支持。伊利诺伊大学 匹兹堡阿尔茨海默病研究中心(PITT-ADRC)编制了一个数据库，其中包括 纵向收集的关于30年来收集的4700多名参与者的信息。DMSc 与PIT-ADRC人员合作，最大限度地提高数据的完整性和准确性 继续维护和加强具有复杂质量控制措施的系统，以捕获和 将数据计算机化，并促进核心项目人员的工作，并最终促进开发项目人员的工作。 这些数据的一部分与国家阿尔茨海默氏症协调中心和批准的 PIT-ADRC数据的接受者。DMSc人员还支持PITT-ADRC数据库的授权用户 通过准备报告、创建用于分析的数据集、提供编程和分析咨询 和支持，并充当诚实的中间人来获取受保护的数据。DMSC人员可用于 在数据管理、研究设计、研究实施、数据方面的协助和协作 分析和数据展示。 为促进PIT-ADRC的教育使命做出贡献，并鼓励更广泛地传播PIT- ADRC数据，DMSc继续开发共享的阿尔茨海默氏症登记处(SHARE)数据集，其中包括 关于PITT-ADRC参与者的大量数据的子集，以及允许用户 具有查询SQL Server数据库权限的权限，方便和扩大其使用范围。 DMSc发起了一个方法学工作组(MWG)，该工作组为培训任务提供服务，并提供 开发和分享与AD研究相关的创新方法的论坛。这个工作组 包括高级和早期职业方法专家，拥有广泛的统计专业知识，来自 对AD研究感兴趣的匹兹堡大学，其中几个人利用了PIT-ADRC 数据。MWG的首要目标是促进进一步的方法论工作，将DMSc能力扩展到 与ADRC研究人员合作，并作为培训和指导下一代AD的中心 研究人员。MWG模式促进了多学科研究，能够推动我们的 了解阿尔茨海默病的病因和发病机制，有助于推动有效治疗的发展。

Data Management and Statistics Core: Summary/Abstract: The Data Management and Statistics Core (DMSC) facilitates research and collaborations with local Alzheimer’s disease (AD) researchers, national initiatives and others by providing high quality data management and methodological support. The University of Pittsburgh Alzheimer's Disease Research Center (PITT-ADRC) has compiled a database that includes information collected longitudinally about more than 4700 participants collected over 30 years. The DMSC works with PITT-ADRC personnel to maximize data completeness and accuracy having developed, and continuing to maintain and enhance, systems with sophisticated quality control measures for capturing and computerizing data and for facilitating the work of Core and, ultimately, Developmental project personnel. Portions of these data are shared with the National Alzheimer’s Coordinating Center and with approved recipients of PITT-ADRC data. DMSC personnel also support authorized users of the PITT-ADRC database by preparing reports, creating datasets used for analyses, providing programming and analytical consultation and support, and serving as Honest Broker to obtain protected data. DMSC personnel are available for assistance and collaborations concerning data management, study design, study implementation, data analysis, and data presentation. To contribute to the educational mission of the PITT-ADRC, and to encourage wider dissemination of PITT- ADRC data, the DMSC continues to develop the SHared Alzheimer's REgistry (SHARE) dataset that includes a subset of the extensive data about PITT-ADRC participants and the user-friendly system that allows users with approved access to query the SQL Server database to facilitate and expand its use. The DMSC has initiated a Methodology Working Group (MWG) that serves a training mission and provides a forum for developing and sharing innovative methodologies relevant to AD research. This working group includes senior-level and early career methodologists, with a broad range of statistical expertise, from across the University of Pittsburgh who are interested in AD research, several of whom have utilized PITT-ADRC data. The overarching goal of the MWG is to foster further methodologic work, to expand DMSC abilities to collaborate with ADRC researchers, and to serve as a hub for training and mentoring the next generation of AD researchers. The MWG model promotes multidisciplinary research with the capability to further our understanding of AD etiology and pathogenesis to help drive the development of effective therapies.