Bioassay Facility Core

抽象-生物分析设备核心 地球中心生物分析设施核心将提供所需的使能技术和专业知识 推进加州大学旧金山分校地球中心研究社区的跨学科环境研究。这个 地球中心生物分析设施核心将提供几个设施来覆盖地球中心的大部分 研究人员需要：1)广泛的生物监测设施，在许多情况下提供化学检测和测量 不同的媒介，包括空气、水、土壤、危险废物、消费品和生物或人类 组织；2)最新的条带质谱仪以及用于评估化学物质的传统蛋白质组学 对生物过程的影响；3)获得广泛的化学库，并有能力执行高 在模型生物体和组织培养中进行体内化学筛选；4)新型人体异种移植 将组织移植到老鼠体内，以更真实地模拟化学暴露。因此，地核将使地球中心 研究人员通过提供高通量、高效率和低成本的 有效的化学评价技术。

ABSTRACT - BIOASSAY FACILITY CORE The EaRTH Center Bioassay Facility Core will provide the enabling technology and expertise needed to advance cross-disciplinary environmental studies across the UCSF EaRTH Center research community. The EaRTH Center Bioassay Facility Core will offer several facilities to cover the majority of the EaRTH Center researchers needs: 1) an extensive biomonitoring facility providing chemical detection and measurement in many different media including air, water, soil, hazardous waste streams, consumer products and biological or human tissues; 2) state of the art SWATH mass spectrometry as well as traditional proteomics for assessing a chemical's effect on biological processes; 3) access to an extensive chemical library combined with ability to perform high- throughput in vivo chemical screening in a model organism and tissue culture; 4) novel xenografting of human tissue into mice to more realistically model chemical exposures. The Core therefore will enable EaRTH Center researchers to push the boundaries of environmental research by providing high-throughput, efficient and cost- effective chemical evaluation technologies.